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Provider review

SkyRx Review: Price, Pros & Cons

By The WeighLab Bench, Tools & Data Desk

SkyRx is a telehealth service selling compounded semaglutide as an injection or under-the-tongue drops, with a headline $199 a month that requires a 12-month plan paid in full up front; tirzepatide is listed as coming soon.

In this review

Compounded drugs are not FDA-approved. Treatment requires a clinician's assessment. Understand compounded GLP-1 treatment.

Check SkyRx prices Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. See our disclosure.

Prices at a glance

Semaglutide
$199/mo12-month plan paid up front, compounded injection or oral drops; month-to-month price not published
Tirzepatide
Not disclosed
Coverage
Coverage not published
Brand-name
Not confirmed

Semaglutide · estimated annual cost

$2,388

Who SkyRx may suit

Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.

Where the value is

  • Semaglutide comes as a weekly injection or daily oral drops
  • The price includes the medication, supplies, doctor visit and shipping
  • A written weight-loss guarantee: a refund of the first four months of medication costs if you don't lose 10% in 16 weeks, under its terms
  • LegitScript certified

The tradeoffs

  • The '$199/mo' price is a 12-month plan paid in full up front, and no month-to-month price is published
  • Tirzepatide is listed as 'coming soon'
  • No medical director or named compounding pharmacy, and no state list
  • All sales are final once medication is dispensed

What the $199 price means

SkyRx advertises compounded semaglutide "starting at $199/mo." Its own fine print explains the condition: that rate is for a 12-month subscription paid up front, in full. SkyRx doesn't publish a month-to-month price, so ask for it before you decide.

SkyRx says its price is one monthly figure that covers the medication, supplies, the doctor visit and shipping. Semaglutide comes as a weekly injection or as oral drops you take under your tongue, both at the same headline price. Tirzepatide injections and drops are listed as coming soon.

Considering SkyRx?

Check the plan total, billing period and cancellation terms before you enroll. A clinician decides whether treatment is appropriate.

The weight-loss guarantee

SkyRx offers a money-back guarantee, and its terms are specific. If you don't lose at least 10% of the starting weight you reported in your intake after your first 16 weeks of receiving and properly dosing the medication, you can ask for a refund of your first four months of medication costs.

You have to email a request and submit a verification, and SkyRx makes the final decision at its own discretion. Approved refunds are paid within 30 days and don't include other costs.

Who prescribes and who fills it

You take a short eligibility quiz, and a licensed provider in your state reviews it. Once approved, a U.S.-based compounding pharmacy ships the medication. SkyRx says its pharmacies are 503B facilities registered with the FDA, but it doesn't name them. GLP-1s aren't available in every state, and SkyRx doesn't list which ones it covers.

Canceling and returns

SkyRx says there are no contracts and you can cancel a shipment anytime by email or from your patient account. Its terms describe subscriptions that renew automatically until you cancel, and note that the first renewal may come earlier than scheduled. Returns aren't accepted, and all sales are final. Check how canceling works on a 12-month plan you've already paid for before you buy one.

The Index scorecard

SkyRx scored on our six Cost-Efficiency Index factors. See the methodology.

Normalized Cost/Month51/100
Price Transparency86/100
Nationwide Access24/100
Formulation Options64/100
Clinical Oversight76/100
Contract Flexibility20/100

The bottom line

SkyRx is a telehealth service selling compounded semaglutide as an injection or under-the-tongue drops, with a headline $199 a month that requires a 12-month plan paid in full up front; tirzepatide is listed as coming soon.

Compare the total cost of other GLP-1 programs and alternatives to SkyRx before deciding. A clinician should help you choose the right treatment.

Other programs to compare with SkyRx

These are partners: we may earn a commission if you sign up, at no cost to you.

  • Peter MDPartner

    Semaglutide modeled $149/mo · Tirzepatide modeled $249/mo

    One account across six verticals — TRT, ED, weight loss, GLP-1, men's hair loss and NAD+ — from a physician-prescribed telehealth brand running since 2021, at a renewal price ($249/mo tirzepatide) well above its own $149 first-month headline.

  • WellorithmPartner

    brand-name Semaglutide modeled $899/mo · brand-name Tirzepatide modeled $1,199/mo

    Wellorithm sells brand Wegovy at $899 a month and Zepbound or Ozempic at $1,199, with compounded semaglutide and dissolving tablets offered but not priced until you start the quiz.

  • Direct MedsPartner

    Semaglutide modeled $249/mo · Tirzepatide modeled $299/mo

    Direct Meds sells semaglutide and tirzepatide both as a sublingual and as an injection, every product priced in the open, from $249 a month on a plan that bills against a 90-day supply.

Compare with other providers

The providers whose Cost-Efficiency Index scores sit closest to SkyRx's. See the alternatives to SkyRx.

Explore more provider reviews

Pricing, states and verification reflect SkyRx's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on SkyRx's site. Not medical advice; see our disclosure.

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