Direct Meds review
The widest set of routes in this ranking — sublingual and injection on both semaglutide and tirzepatide, every SKU priced in the open — sold well above the median, on a plan that only ever bills against a 90-day supply.
- Semaglutide
- $249/mo (sublingual, 90-day supply billed monthly)
- Tirzepatide
- $299/mo (sublingual, 90-day supply billed monthly)
- Coverage
- Not disclosed
- Brand-name
- Compounded only
Semaglutide · modeled / year
$2,988
Tirzepatide · modeled / year
$3,588
Pricing verified August 2026
The Index scorecard
Direct Meds scored on our six Cost-Efficiency Index factors. See the methodology.
Where the value is
- Sublingual AND injection on BOTH molecules — four GLP-1 SKUs, the widest formulation range of any provider in this ranking
- Every price is published per SKU in a public shop, with no quiz, intake or email capture in front of it
- Each product page prints a per-day equivalent beside the monthly rate ($8.03/day at $249), which is unusually concrete for this category
- Free shipping, no monthly membership fee and no hidden fees are stated on every product page
- Sermorelin and NAD+ sit in the same catalog for anyone already buying a GLP-1 there
The tradeoffs
- $249/mo sublingual is well above this ranking's ~$144 median, and the injection route is $297 — the cheapest thing here is dearer than most rows' headline price
- The only purchasable option on every product page is a 90-DAY SUPPLY billed monthly, so three months is the smallest unit sold — there is no month-to-month rate to compare against the rows beside it
- Every headline figure is framed "AS LOW AS", yet the only available option shows "0% OFF" — the framing implies a cheaper tier that is not actually on sale
- No state list is published, so coverage cannot be checked before signing up
- The compounding pharmacy is never named, and we found no LegitScript listing — the same unnamed-clinical-layer gap that caps several rows in this ranking
- No FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- The site's own social proof does not agree with itself: the weight-loss page says "4.6" and "over 250,000+ happy customers", while the product pages say "4.5" and "100,000+ Happy Customers" — so we cite no customer count or rating for it at all
The bottom line
Best for: Needle-averse shoppers who want a sublingual route on either molecule and will pay above the going rate for it, having accepted a three-month supply as the smallest unit sold. The widest set of routes in this ranking — sublingual and injection on both semaglutide and tirzepatide, every SKU priced in the open — sold well above the median, on a plan that only ever bills against a 90-day supply.
Ranked #64 of 539 providers on the Cost-Efficiency Index — see our #1 pick, CoreAge Rx, for comparison.
Compare with other providers
All 538 other providers we've modeled, in Cost-Efficiency Index order. See the ranked alternatives to Direct Meds.
- #76Heally— Heally is a per-order (not subscription) telehealth platform for GLP-1 prescriptions, care delivered by HLY Medical Group PA, with semaglutide starting at $149/mo and tirzepatide at $299/mo.72/100
- #77Recovery Delivered— Recovery Delivered is primarily an online addiction/recovery telehealth brand (buprenorphine treatment is its lead offering) that also runs a real, separately priced GLP-1 weight-loss vertical.72/100
- #78Nova— Nova (trynova.co) bundles the medication, refrigerated shipping and a $99 monthly membership into one figure — $198 for semaglutide and $210 for tirzepatide — and serves 49 states, everywhere except California.72/100
- #79Bodybuilding Health+— The Bodybuilding.com fitness brand's telehealth arm, with a genuinely descending semaglutide ladder — and a twelve-month tirzepatide rung badged Best Value while costing more than the six-month one.69/100
- #80Apex MD— Apex MD is a nationwide telehealth platform selling compounded semaglutide and tirzepatide bundled with NAD, B-12, and L-carnitine (not single-ingredient GLP-1) at a flat $299/mo and $399/mo month-to-month respectively.71/100
- #81GOAL.MD— GOAL.MD (goal.md) is a physician-run telehealth weight-loss practice, led by Chief Physician Dr. Michael Mimlitz, MD.71/100
The 18 programs nearest this one
Pricing, states and verification reflect Direct Meds's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Direct Meds's site. Not medical advice; see our disclosure.