Polly Review: Price, Pros & Cons
Polly's advertised $135 and $199 prices are billed weekly, not monthly, so the real monthly cost is roughly $585 for semaglutide and $862 for tirzepatide.
- Semaglutide
- $135/week$585/mo equiv.
- Tirzepatide
- $199/week$862/mo equiv.
- Coverage
- All 50 states
- Brand-name
- Compounded only
Semaglutide · modeled / year
$7,020
Tirzepatide · modeled / year
$10,344
The Index scorecard
Polly scored on our six Cost-Efficiency Index factors. See the methodology.
Where the value is
- Names two specific 503A partner compounding pharmacies (Hallandale Pharmacy, VialsRx) rather than staying anonymous
- Nationwide all-50 access with flat pricing at every dose
- Displays a LegitScript certification seal
The tradeoffs
- The headline $135/$199 prices are billed WEEKLY, not monthly — the real monthly-equivalent cost is roughly $585 (semaglutide) and $862 (tirzepatide)
- Compounded only — no brand-name or oral route
The bottom line
Best for: Shoppers who understand the pricing is billed weekly and want a flat, dose-independent recurring charge from a named pharmacy. Polly's advertised $135 and $199 prices are billed weekly, not monthly, so the real monthly cost is roughly $585 for semaglutide and $862 for tirzepatide.
For comparison, read our review of CoreAge Rx, one of our partners. Partners are listed first on our leaderboard; every provider is scored on the same six factors.
Other programs to compare with Polly
These are partners: we may earn a commission if you sign up, at no cost to you.
ShedRx (Shed)Partner
Semaglutide from $199/mo · tirzepatide from $299/mo
Shed sells its GLP-1s as an injection, drops, lozenges or a daily pill, with brand-name Zepbound too; month to month, semaglutide is $199 and tirzepatide $299.
Strut HealthPartner
Semaglutide from $99/mo · tirzepatide from $149/mo
Strut sells compounded semaglutide from $99 a month as a lozenge or $129 as a weekly injection, and tirzepatide from $149, all on auto-refill.
bmiMDPartner
Semaglutide from $159/mo · tirzepatide from $249/mo
bmiMD charges $159 a month for compounded semaglutide and $249 for tirzepatide month to month, the same at every dose, with lower prices on three-, six- and twelve-month plans.
Compare with other providers
The providers whose Cost-Efficiency Index scores sit closest to Polly's. See the alternatives to Polly.
- Walgreens Weight Management— Walgreens Weight Management is a self-pay virtual-care add-on launched February 26, 2026, connecting eligible adults (18-64) in 29 states with licensed clinicians for a $49-per-visit consultation.66/100
- Vital Edge— Vital Edge lists a flat $350 a month for compounded semaglutide and $450 for tirzepatide, plus brand Ozempic, Wegovy, Mounjaro and Rybelsus, but publishes no cancellation or refund terms.66/100
- LifeVine Wellness— LifeVine Wellness lists compounded semaglutide from $247 and tirzepatide from $347 a month, but a footnote says those are monthly equivalents of multi-month plans, and the actual price is set after a provider reviews you.66/100
- MyDrHank— Every price this site advertises is a twelve-month prepay rate — its price display returns the cheapest term by design — so the real month-to-month cost is $249-$349, not the "from $171" on the page.65/100
- Collective— Collective sells compounded semaglutide at $59 and tirzepatide at $69 a month, both genuinely medication prices, on top of a $199 annual membership that is required, auto-renewing and not refundable.65/100
- Primary Clinic (Direct GLP)— A Direct Primary Care membership rather than a GLP-1 storefront: $85 semaglutide and $133 tirzepatide sit on top of an $89/mo membership the FAQ says does not include the drug.65/100
The 20 programs nearest this one
Pricing, states and verification reflect Polly's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Polly's site. Not medical advice; see our disclosure.