Cost Plus Drugs review
Mark Cuban's transparent-pricing online pharmacy.
- Semaglutide
- $279/mo (brand Ozempic)
- Tirzepatide
- Not disclosed
- Coverage
- All 50 states
- Brand-name
- Yes
Semaglutide · modeled / year
$3,348
The Index scorecard
Cost Plus Drugs scored on our six Cost-Efficiency Index factors. See the methodology.
Where the value is
- Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- Around $279/mo for branded Ozempic — well below typical retail list prices
- Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
- Ships to all 50 states; genuine FDA-approved Novo Nordisk Ozempic, not compounded
- Partnered with 9amHealth so you can get prescribed and fill at Cost Plus pricing
The tradeoffs
- Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
- Wegovy availability has been spotty — check current stock before assuming it ships
- No compounded semaglutide or tirzepatide — brand only
- No clinical follow-up — side-effect monitoring falls to your prescribing clinician
The bottom line
Best for: Cost-first shoppers who want the cheapest transparent-pricing brand-name Ozempic channel. Mark Cuban's transparent-pricing online pharmacy.
Ranked #167 of 492 providers on the Cost-Efficiency Index — see our #1 pick, CoreAge Rx, for comparison.
Compare with other providers
All 491 other providers we've modeled, in Cost-Efficiency Index order. See the ranked alternatives to Cost Plus Drugs.
- #176TeleCareSpot— TeleCareSpot is a telehealth weight-loss platform offering doctor-prescribed compounded GLP-1s with flat, all-inclusive monthly pricing: compounded semaglutide at $299/month and tirzepatide at $399/month…64/100
- #177Tru2u— Tru2u is a US direct-to-consumer telehealth and wellness store offering provider-guided compounded GLP-1 weight-loss therapy alongside hair, skincare, and supplement lines.64/100
- #178Unique Physique— Unique Physique is a hybrid in-office and telehealth weight-loss clinic in Baton Rouge, Louisiana, with medical oversight from Reena John, DO.64/100
- #17910rx— 10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin…63/100
- #180Calibrate Health— Calibrate Health is a year-long metabolic-reset program pairing branded GLP-1 medication (Wegovy, Ozempic, Zepbound, or Foundayo) with 1:1 video coaching and dietitian support — a deeper clinical wrap than…63/100
- #181Center for Medical Weight Loss (CMWL)— Center for Medical Weight Loss (CMWL) runs a 100 percent online, physician-supervised GLP-1 program using compounded semaglutide and tirzepatide with flat any-dose pricing.63/100
The 18 programs nearest this one
- #168 Healthicare64
- #169 Injectco64
- #170 Lavender Sky Health64
- #171 LIV by WellNow64
- #172 LumiMeds64
- #173 Nova MD64
- #174 NuDay Rx64
- #175 Remote Pharmacy64
- #182 Corsica Health63
- #183 Curve63
- #184 ElitePhysiqMD63
- #185 Fierce Health63
- #186 FitFlow63
- #187 Harbor63
- #188 InstaRX63
- #189 Jently63
- #190 Knownwell63
- #191 Lttl63
Pricing, states and verification reflect Cost Plus Drugs's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Cost Plus Drugs's site. Not medical advice; see our disclosure.