Cost Plus Drugs Review: Pros & Cons
Mark Cuban's transparent-pricing online pharmacy.
In this review
Not available to order
Cost Plus Drugs is a mail-order pharmacy. It fills prescriptions but doesn't prescribe, so you need a prescriber first.
Looking for a GLP-1 program you can start online? See the cheapest GLP-1 providers or the leaderboard.
Where the value is
- Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- Around $279/mo for branded Ozempic — well below typical retail list prices
- Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
- Ships to all 50 states; genuine FDA-approved Novo Nordisk Ozempic, not compounded
- Partnered with 9amHealth so you can get prescribed and fill at Cost Plus pricing
The tradeoffs
- Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
- Wegovy availability has been spotty — check current stock before assuming it ships
- No compounded semaglutide or tirzepatide — brand only
- No clinical follow-up — side-effect monitoring falls to your prescribing clinician
Cost Plus Drugs fills prescriptions, it doesn't write them
Cost Plus Drugs is a mail-order pharmacy known for selling medications at a published markup over what it pays for them. It fills prescriptions, but it doesn't write them, so it can't start you on a GLP-1 by itself.
If you already have a prescription from your doctor or a telehealth company, you can ask whether Cost Plus stocks your medication and what it charges, since its catalog changes over time. To get a prescription in the first place, you'll need a licensed provider who handles the medical review and decides on the dose. To start treatment, compare compounded semaglutide providers or compounded tirzepatide providers.
The bottom line
Mark Cuban's transparent-pricing online pharmacy.
Compare the total cost of other GLP-1 programs and alternatives to Cost Plus Drugs before deciding. A clinician should help you choose the right treatment.
GLP-1 programs you can start online
These are partners: we may earn a commission if you sign up, at no cost to you.
Strut HealthPartner
Semaglutide modeled $99/mo · Tirzepatide modeled $149/mo
Strut sells compounded semaglutide from $99 a month as a lozenge or $129 as a weekly injection, and tirzepatide from $149, all on auto-refill.
bmiMDPartner
Semaglutide modeled $159/mo · Tirzepatide modeled $249/mo
bmiMD charges $159 a month for compounded semaglutide and $249 for tirzepatide month to month, the same at every dose, with lower prices on three-, six- and twelve-month plans.
RxSpan MDPartner
Semaglutide modeled $249/mo · Tirzepatide modeled $329/mo
RxSpan MD puts injections, oral capsules and three brand-name drugs on one account, with every price and plan length published; one month of the semaglutide injection is $249.
Compare with other providers
More GLP-1 providers we have reviewed. See the alternatives to Cost Plus Drugs.
- Remedy Meds— Remedy Meds charges $299 every four weeks for compounded semaglutide and $399 for tirzepatide at every dose, with brand Ozempic and Zepbound on the same menu, but shows none of those prices until you have finished its health quiz.64/100
- Novera MD— Novera MD lists compounded semaglutide starting at $94.31 a month and tirzepatide at $164.31, but it doesn't say what plan length those figures belong to or what a month costs on its own.64/100
- Rehydra+ Wellness— Rehydra+ Wellness sells four-week supplies of compounded semaglutide from $149 and tirzepatide from $219 with no contract, while its cheaper monthly memberships lock you in for six months.64/100
- Trava Health— Trava Health offers compounded semaglutide and tirzepatide on monthly or prepaid quarterly plans, with prices that depend on the prescribed dose.63/100
- VirtualCare2Go— VirtualCare2Go is a Texas telehealth practice with three all-inclusive weight-loss tiers: compounded semaglutide at $279 a month, semaglutide tablets at $599 and an injection tier at $629.63/100
- Fitness RX— Fitness RX combines GLP-1 treatment with clinician care and a BodyFX fitness-app subscription, with your medication and full price confirmed after intake.63/100
Pricing, states and verification reflect Cost Plus Drugs's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Cost Plus Drugs's site. Not medical advice; see our disclosure.