Rylo Health review
Rylo Health is a compounded GLP-1/NAD+/peptide telehealth platform operating in all 50 states through Lone Star Virtual Health PLLC and dispensing via VialsRX in Houston, TX.
- Semaglutide
- $149/mo (all doses, promotional rate, compounded)
- Tirzepatide
- $249/mo (all doses, compounded)
- Coverage
- All 50 states
- Brand-name
- Compounded only
Semaglutide · modeled / year
$1,788
Tirzepatide · modeled / year
$2,988
Pricing verified August 2026
The Index scorecard
Rylo Health scored on our six Cost-Efficiency Index factors. See the methodology.
Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review, and shipping all stated as included in the quoted price with no add-ons found
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
- HSA/FSA accepted per the site
- LegitScript badge displayed
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The advertised 'quarterly $349/$499' option's actual billing mechanics (one-time total vs. recurring monthly-under-commitment) could not be verified — the product pages that would clarify this render via JavaScript and returned no readable pricing text
- No named individual prescriber or medical director, only the provider group name
- No lab testing, COA, or FDA-warning-letter disclosure found on the site
The bottom line
Best for: Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases. Rylo Health is a compounded GLP-1/NAD+/peptide telehealth platform operating in all 50 states through Lone Star Virtual Health PLLC and dispensing via VialsRX in Houston, TX.
Ranked #52 of 539 providers on the Cost-Efficiency Index — see our #1 pick, CoreAge Rx, for comparison.
Compare with other providers
All 538 other providers we've modeled, in Cost-Efficiency Index order. See the ranked alternatives to Rylo Health.
- #43Enhance MD— The clearest tiered price ladder in this ranking — separate published lines for semaglutide, tirzepatide, a microdose tier and a sema+tirz combo — with lab work built into every tier.75/100
- #44PreventiveMD— PreventiveMD is a physician-guided telehealth platform for GLP-1 weight loss and peptide therapy, offering compounded semaglutide from $83/mo all-in and compounded tirzepatide from $97/mo all-in.77/100
- #45Rx.com— Prints "No automatic renewals" on the plan card and names the pharmacy that dispenses, with a street address — then advertises another drug's prepay rate.77/100
- #46HealthRX— Publishes its entire term ladder as machine-readable data — and advertises the twelve-month rung, so the price on the tin is roughly half the price you pay month to month.74/100
- #47Pallas Health— Prices both molecules openly and bills them in 12-week blocks — $597 and $897 up front, with no monthly option to fall back on.74/100
- #48EverSlim— EverSlim is a US telehealth program selling doctor-prescribed compounded GLP-1 medication delivered to the door, with compounded semaglutide from $117 a month and compounded tirzepatide from $140 a month.76/100
The 24 programs nearest this one
- #53 Synergy Rx72
- #54 Peter MD72
- #55 EdgeRx74
- #56 Amble74
- #57 Aspen74
- #58 DoctorAdam74
- #59 Jyra Health74
- #60 Nalena74
- #61 NextMeds74
- #62 Science & Co74
- #63 Gala Health71
- #64 Direct Meds71
- #65 He & She MD71
- #66 SkinnyRx71
- #67 Amazon One Medical73
- #68 MyFastRx73
- #69 Navio MD73
- #70 Ozari Health73
- #71 Trillium Meds73
- #72 Clume Health73
- #73 BiltRx72
- #74 Candor Rx72
- #75 Get Thin MD72
- #76 Heally72
Pricing, states and verification reflect Rylo Health's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Rylo Health's site. Not medical advice; see our disclosure.