Rx.com Review: Price, Pros & Cons
Offers a flat price at every dose, no automatic renewals and a named dispensing pharmacy, with lower rates on prepaid plans.
In this review
Compounded drugs are not FDA-approved. Treatment requires a clinician's assessment. Understand compounded GLP-1 treatment.
Prices at a glance
- Semaglutide
- $175/moMonth-to-month; $165 on three months, $146 on six and $99 on twelve, prepaid
- Tirzepatide
- $285/moMonth-to-month; $265 on three months, $259 on six and $149 on twelve, prepaid
- Coverage
- 47 states on its program page; product pages say 49
- Brand-name
- Not confirmed
Semaglutide · estimated annual cost
$2,100
Tirzepatide · estimated annual cost
$3,420
Who Rx.com may suit
Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.
Where the value is
- "No automatic renewals" is printed under the plan card itself rather than buried in the terms
- Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
- One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included
- A provider who declines to prescribe does not charge for medication
The tradeoffs
- The $99/mo semaglutide and $149/mo tirzepatide headlines require a 12-month prepayment of $1,188 or $1,788
- Its program page excludes Alaska, Louisiana and Mississippi, while product pages exclude only Alaska; confirm coverage before paying
- Injection only — no oral route and no brand-name lane
- A separate program page quotes higher monthly prices than its product cards; confirm your plan total at checkout
How Rx.com prices its GLP-1 plans
Rx.com is best known for its pharmacy discount card, and its weight-loss program is a separate cash-pay service. It sells two compounded weekly injections, semaglutide and tirzepatide, and the price depends only on the drug and the plan length you choose. It never changes with your dose. Your provider can step you from 2.5 mg up to 15 mg of tirzepatide, or from 0.25 mg up to 2.4 mg of semaglutide, and your plan price stays the same.
Month to month, semaglutide is $175 and tirzepatide is $285 on the product cards. The annual plans are $1,188 and $1,788 paid up front. A separate program page quotes higher prices, so confirm the total on your chosen plan before paying. Longer plans cost less per month. The lowest monthly figure Rx.com advertises is its 12-month plan, which is charged as one payment up front. Before you check out, compare that total with the shorter plans, and pick the length you're confident you'll finish. Tirzepatide costs more than semaglutide on every plan.
Considering Rx.com?
Check the plan total, billing period and cancellation terms before you enroll. A clinician decides whether treatment is appropriate.
What one price covers
Rx.com says there are no visit fees, membership fees, dose upcharges or shipping charges. The plan price includes:
- the online provider visit and follow-ups
- your medication at whatever dose is prescribed
- syringes, alcohol pads and a dosing guide
- cold-packed, discreet shipping
- unlimited messaging with your care team
It doesn't bill insurance. You pay by debit or credit card, and many HSA and FSA cards work.
Who qualifies and how it works
The program is for adults 18 and older with a BMI of 30 or more, or 27 or more with a weight-related condition such as high blood pressure, sleep apnea or type 2 diabetes. You pick a drug and plan, check out, then complete a health questionnaire and upload a photo ID. Some states add a short video visit.
A provider licensed in your state usually reviews it within 24 hours. If you aren't approved, you aren't charged for medication. Prescriptions are prepared by a licensed U.S. compounding pharmacy and shipped cold-packed. Rx.com describes itself as a marketplace that connects patients with independent providers, and it doesn't dispense the drugs itself.
The program page lists 47 states, excluding Alaska, Louisiana and Mississippi. Its product pages say 49 states, excluding only Alaska, so confirm your state before paying.
Refills and canceling
Plans don't renew automatically. Before each refill, your care team checks in with you, and nothing ships or gets charged until you confirm. You can pause or cancel from your account at any time with no fee.
Medication sales are final once a package ships, and it can't be returned. If you buy a long plan up front, ask how the months that haven't shipped are handled if you stop early, since the FAQ doesn't say.
The Index scorecard
Rx.com scored on our six Cost-Efficiency Index factors. See the methodology.
The bottom line
Offers a flat price at every dose, no automatic renewals and a named dispensing pharmacy, with lower rates on prepaid plans.
Compare the total cost of other GLP-1 programs and alternatives to Rx.com before deciding. A clinician should help you choose the right treatment.
Other programs to compare with Rx.com
These are partners: we may earn a commission if you sign up, at no cost to you.
MEDGmPartner
Semaglutide modeled $299/mo · Tirzepatide modeled $399/mo
MEDGm charges $299 a month for compounded semaglutide injections and $399 for tirzepatide once the $120 welcome coupon lapses, prints every plan length on its product pages, and names the four pharmacies that fill its prescriptions.
Luvo HealthPartner
Semaglutide modeled $226.42/mo · Tirzepatide modeled $269.75/mo
Luvo charges $209 every four weeks for compounded semaglutide and $249 for tirzepatide, with half off the first delivery and brand-name Ozempic or Zepbound available.
MyDrHankPartner
Semaglutide modeled $249/mo · Tirzepatide modeled $349/mo
Every price this site advertises is a twelve-month prepay rate — its price display returns the cheapest term by design — so the real month-to-month cost is $249-$349, not the "from $171" on the page.
Compare with other providers
The providers whose Cost-Efficiency Index scores sit closest to Rx.com's. See the alternatives to Rx.com.
- Happy Care Meds— Happy Care Meds offers dose-priced compounded injections in 28-day supplies, with higher-dose maintenance quotes of $139 semaglutide and $209 tirzepatide.77/100
- TrimRx— TrimRx's terms price compounded semaglutide at $199 for the first month and $299 a month after, and tirzepatide at $349 then $399, while its homepage advertises both from $179 and $259.77/100
- StaveMD— StaveMD lists compounded semaglutide, as a weekly shot or a dissolving tablet, from $199 a month and tirzepatide from $249, with a refund on any month whose medication hasn't been ordered yet.77/100
- Enhance MD— Enhance MD charges $212 a month for compounded semaglutide and $280 for tirzepatide at every dose, with lab work every six months included; the first month is $100 less.76/100
- Henry Meds— Henry Meds sells sublingual semaglutide from $179 a month, the injection at $297, and tirzepatide only as tablets in a $1,047 three-month supply, with visits, medication and shipping in one price.76/100
- EverSlim— EverSlim is a US telehealth program selling doctor-prescribed compounded GLP-1 medication delivered to the door, with compounded semaglutide from $113 a month and compounded tirzepatide from $136 a month.76/100
Pricing, states and verification reflect Rx.com's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Rx.com's site. Not medical advice; see our disclosure.