Lyfe Rx review
Lyfe Rx offers compounded semaglutide ($289) and compounded tirzepatide ($399).
- Semaglutide
- $225/mo (compounded)
- Tirzepatide
- $299/mo (compounded)
- Coverage
- Coverage not published
- Brand-name
- Compounded only
Semaglutide · modeled / year
$2,700
Tirzepatide · modeled / year
$3,588
The Index scorecard
Lyfe Rx scored on our six Cost-Efficiency Index factors. See the methodology.
Where the value is
- Both compounded semaglutide and tirzepatide available
- Delivery to all 50 states with 1–3 day pharmacy turnaround
The tradeoffs
- No visible LegitScript or PCAB accreditation
- Also sells non-prescription supplements ('Tirzepatide Weight Loss Supplement', 'Lipo Burn')
- Shopify-based e-commerce storefront — less clinical infrastructure
- FDA issued this company a warning letter dated 9 September 2025; the letter is public in FDA's warning-letter database
The bottom line
Best for: Cost-first shoppers who want use with caution — FDA warning letter on file. Lyfe Rx offers compounded semaglutide ($289) and compounded tirzepatide ($399).
Ranked #268 of 492 providers on the Cost-Efficiency Index — see our #1 pick, CoreAge Rx, for comparison.
Compare with other providers
All 491 other providers we've modeled, in Cost-Efficiency Index order. See the ranked alternatives to Lyfe Rx.
- #266Human+— Human+ (HUMAN+, INC.) is an 'at-cost' telehealth membership in all 50 states: you pay a flat monthly fee and prescriptions are billed at pharmacy-wholesale cost rather than marked up.58/100
- #267Lean Rx— Lean Rx is a Sacramento-based telehealth technology platform offering compounded GLP-1 weight loss medications.58/100
- #269Transparent Meds— Transparent Meds is an online GLP-1 weight-care service that connects you with licensed medical providers and leads with upfront pricing: compounded weekly injections of semaglutide at an intro $149/month…58/100
- #270DreamHug Medical— DreamHug Medical is a direct-to-consumer telehealth weight-loss platform offering semaglutide and claiming all-50-state coverage through a large affiliated doctor network.57/100
- #271Eloria— Eloria is a clinician-led GLP-1 weight-loss telehealth platform operated by Arora Health & Aesthetics.57/100
- #272Emerge Weight Loss— Emerge Weight Loss is a nationwide telehealth platform focused specifically on compounded tirzepatide for medical weight management.57/100
The 20 programs nearest this one
- #273 Form Health57
- #274 Joey Med57
- #275 Luci57
- #276 ShapeIn Rx57
- #277 SkyRx57
- #278 Somira Health57
- #279 Vitalex Health57
- #280 Alegro Health56
- #281 ARSYNL Rx56
- #282 Invyncible56
- #283 iThriveMD56
- #284 Joi + Blokes56
- #285 KERNX Health56
- #286 LunaRx56
- #287 Silhouette MD56
- #288 Spry56
- #289 Trinity Meds56
- #290 Willow56
- #291 Woodwork56
- #292 AquaVita NextGen55
Pricing, states and verification reflect Lyfe Rx's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Lyfe Rx's site. Not medical advice; see our disclosure.