Signos review
Signos is a CGM-first metabolic-health company whose Signos+ plan genuinely bundles clinician-prescribed compounded semaglutide with its FDA-cleared continuous glucose monitor and coaching app.
- Semaglutide
- $199/mo (starting dose, bundle, plus a separate fee, compounded)
- Tirzepatide
- Not disclosed
- Coverage
- Coverage not published
- Brand-name
- Compounded only
Semaglutide · modeled / year
$2,388
Pricing verified August 2026
The Index scorecard
Signos scored on our six Cost-Efficiency Index factors. See the methodology.
Where the value is
- Confirmed as a genuine GLP-1 prescriber, not CGM-only — the Signos+ plan bundles compounded semaglutide with the CGM, verified against the separate $127/mo CGM-only price
- Starting price of $199/month is stated to include both the medication program and the CGM hardware/app
- FDA-cleared CGM hardware paired with an AI-powered coaching app for ongoing glucose-guided tracking
- Free rapid shipping and HSA/FSA eligibility
- Unusually candid about the clinical-authority boundary: states outright that Signos itself doesn't make prescribing decisions
The tradeoffs
- The headline $199/month is a 3- or 6-month PROGRAM rate, not a plain month-to-month subscription, and the page doesn't disclose what happens after the term ends
- Only semaglutide is shown in the bundled program; tirzepatide availability is not confirmed anywhere accessible
- Compounded GLP-1s are not FDA-approved finished products, despite being made in FDA-registered facilities
- Compounding pharmacy partner and states served are not published; prescribing is handled entirely by the third-party OpenLoop Health network
The bottom line
Best for: Cost-first shoppers who want glucose-monitoring data paired with a GLP-1 prescription in one program, if a 3- or 6-month term is acceptable. Signos is a CGM-first metabolic-health company whose Signos+ plan genuinely bundles clinician-prescribed compounded semaglutide with its FDA-cleared continuous glucose monitor and coaching app.
Ranked #486 of 539 providers on the Cost-Efficiency Index — see our #1 pick, CoreAge Rx, for comparison.
Compare with other providers
All 538 other providers we've modeled, in Cost-Efficiency Index order. See the ranked alternatives to Signos.
- #467Roboclinic— RoboClinic is not a dedicated GLP-1 weight-loss brand.45/100
- #468Steady State Health— Steady State Health is a physical therapy clinic in Portland, Maine focused on running rehab, pelvic floor therapy, and sports medicine.45/100
- #469WeightlessRx— WeightlessRx is a direct-to-consumer telehealth provider selling compounded semaglutide and tirzepatide with no separate membership or consultation fees layered on top of the drug price.45/100
- #470HumeCare+— HumeCare is a telehealth weight-loss platform genuinely prescribing semaglutide or tirzepatide (chosen by a named physician) with muscle-preserving B-vitamin supplementation and a proprietary body-composition tracker.42/100
- #4719amHealth— 9amHealth (join9am.com) is a cardiometabolic telehealth platform for diabetes, prediabetes.44/100
- #472eMed— eMed is a digital health platform best known for at-home diagnostics that now runs a clinician-supported GLP-1 weight management program.44/100
The 24 programs nearest this one
- #487 This Gen Wellness44
- #488 Valhalla Vitality44
- #489 Genesis Health43
- #490 Beluga Health43
- #491 BodyLogicMD43
- #492 Defy Medical43
- #493 EmbraceRX43
- #494 Eve43
- #495 EverFit Medical43
- #496 Evolve Telemed43
- #497 JM Integrated Health43
- #498 Medivive43
- #499 OlleveCare43
- #500 Omada Health43
- #501 Push Health43
- #502 RedBox Rx43
- #503 Silhouette MD43
- #504 Transcarent43
- #505 Vida Health43
- #506 Virta Health43
- #507 Glam Health42
- #508 Ambiante Health & Wellness42
- #509 AM Rx42
- #510 Ascend Vitality42
Pricing, states and verification reflect Signos's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on Signos's site. Not medical advice; see our disclosure.