1st Optimal review
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets.
- Semaglutide
- Not disclosed
- Tirzepatide
- Not disclosed
- Coverage
- Coverage not published
- Brand-name
- Compounded only
The Index scorecard
1st Optimal scored on our six Cost-Efficiency Index factors. See the methodology.
Where the value is
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
The tradeoffs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
The bottom line
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. 1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets.
Ranked #478 of 492 providers on the Cost-Efficiency Index — see our #1 pick, CoreAge Rx, for comparison.
Compare with other providers
All 491 other providers we've modeled, in Cost-Efficiency Index order. See the ranked alternatives to 1st Optimal.
- #484TRT Kingdom— TRT Kingdom is a hormone-therapy telehealth platform (co-founded by bodybuilder Jay Cutler) offering TRT, peptides, weight loss, and wellness for men and women.40/100
- #485WellMedRx— WellMedRx is a multi-product compounded telehealth platform pairing GLP-1 weight-loss care with TRT, hair-loss, and sexual-health programs under one account.40/100
- #486Wellspring Longevity Clinic— Wellspring Longevity Clinic is a longevity-focused telehealth service offering compounded GLP-1 (semaglutide) and dual GLP-1/GIP (tirzepatide) for weight management, plus NAD+, peptide therapy, and GLP-1…40/100
- #487Bodyshop Wellness— Bodyshop Wellness is an all-in-one wellness platform offering medical weight loss alongside hormone replacement, peptide therapy, vitamin injections, hair loss, and ED treatment under a 'whole body…39/100
- #488EllieMD— Women-focused telehealth weight loss clinic offering GLP-1 prescriptions.39/100
- #489Vital Harmony Rx— Vital Harmony Rx is a telehealth platform offering compounded injectable GLP-1 therapy — semaglutide (GLP-1 + B12) and tirzepatide (GLP-1/GIP + B12) — plus a wellness-peptide menu of NAD+, sermorelin, and…39/100
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Pricing, states and verification reflect 1st Optimal's public disclosures at last review; the Cost-Efficiency Index is our editorial judgment per the methodology. Prices change — confirm on 1st Optimal's site. Not medical advice; see our disclosure.