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WeighLab

Willow vs Cost Plus Drugs

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Willow

Affiliate partner

Shoppers who want an oral-tablet GLP-1 at the same price as the injectable, with no annual commitment.

Semaglutide / month
$299/moCompounded, month to month
Tirzepatide / month
$399/moCompounded, month to month
Index 68/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Willow pricing Read review

Cost Plus Drugs

Provider comparison

Cost Plus Drugs is a mail-order pharmacy. It fills prescriptions but doesn't prescribe, so you need a prescriber first.

Semaglutide / month
$279/moBrand Ozempic
Tirzepatide / month
Not disclosed
Unavailable · Not scoredChecked October 2026

Cost Plus Drugs is a mail-order pharmacy. It fills prescriptions but doesn't prescribe, so you need a prescriber first.

Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

This pair includes a provider that is unavailable for direct GLP-1 enrollment. We do not declare a score winner or compare factor scores when either provider is unavailable.

  • Cost Plus Drugs: Cost Plus Drugs is a mail-order pharmacy. It fills prescriptions but doesn't prescribe, so you need a prescriber first.

Check the difference in state access

Willow
35 states + Puerto Rico
Cost Plus Drugs
All 50 states

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Willow

Cost Plus Drugs

Semaglutide / month
Willow: $299/moCompounded, month to month
Cost Plus Drugs: $279/moBrand Ozempic
Tirzepatide / month
Willow: $399/moCompounded, month to month
Cost Plus Drugs: Not disclosed
Semaglutide / year (modeled)
Willow: $3,588
Cost Plus Drugs: $3,348
Tirzepatide / year (modeled)
Willow: $4,788
Cost Plus Drugs: —
State availability
Willow: 35 states + Puerto Rico
Cost Plus Drugs: All 50 states
Oral / sublingual option listed
Willow: Yes
Cost Plus Drugs: Not listed
Brand-name access listed
Willow: Not confirmed
Cost Plus Drugs: Yes
Provider facts checked
Willow: October 2026
Cost Plus Drugs: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

Review the access limitations and recorded program details. Availability comes before choosing a treatment plan.

Willow

Shoppers who want an oral-tablet GLP-1 at the same price as the injectable, with no annual commitment.

Reasons to consider it

  • Oral tablet formulations of both semaglutide and tirzepatide, priced the same as the injections, $299 and $399 a month
  • Month-to-month billing with no prepay or annual term required to get the advertised rate
  • Named physician team publicly listed, including Chief Medical Officer Dr. Michael Green, MD, plus 11+ other credentialed MDs/DOs

What to weigh up

  • Only 35 states and Puerto Rico are served, so residents of the other 15 states and DC can't sign up
  • Site states medication cost 'varies by dosage and prescription' but never discloses what a higher maintenance dose actually costs beyond the $299/$399 starting figures
  • Compounding pharmacy name and state are not disclosed anywhere on the site

Compounded drugs are not FDA-approved. Understand the medication options.

Check Willow pricing Read the full Willow review

Cost Plus Drugs

Cost Plus Drugs is a mail-order pharmacy. It fills prescriptions but doesn't prescribe, so you need a prescriber first.

Provider background

  • Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
  • Around $279/mo for branded Ozempic — well below typical retail list prices
  • Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News

What to weigh up

  • Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
  • Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
  • Wegovy availability has been spotty — check current stock before assuming it ships

Cost Plus Drugs is a mail-order pharmacy. It fills prescriptions but doesn't prescribe, so you need a prescriber first.

Read the full Cost Plus Drugs review

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.