Head-to-head · Cost-Efficiency Index
Science & Co vs PrescrYbe
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Science & Co
A twelve-month committer, or someone who values a company stating plainly what it is and is not.
Visit Science & CoPrescrYbe
Shoppers who want an injection, an oral tablet or a microdose plan priced up front on one page, and who budget by the four-week cycle rather than the month.
Visit PrescrYbeThe verdict
Science & Co and PrescrYbe tie on the Cost-Efficiency Index at 74/100, so neither wins outright on the numbers, so choose on fit. Science & Co: A twelve-month committer, or someone who values a company stating plainly what it is and is not. PrescrYbe: Shoppers who want an injection, an oral tablet or a microdose plan priced up front on one page, and who budget by the four-week cycle rather than the month.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Science & Co.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Science & Co | PrescrYbe |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 74/100 |
| Semaglutide / mo | $149/moMonth-to-month; $79 only on a twelve-month plan | $249Every 4 weeks (compounded injection; oral $279, microdose $179) |
| Tirzepatide / mo | $199/moMonth-to-month; $125 only on a twelve-month plan | $339Every 4 weeks (compounded injection; microdose $179) |
| Semaglutide / yr (modeled) | $1,788 | $3,23713 charges |
| Tirzepatide / yr (modeled) | $2,388 | $4,40713 charges |
| Coverage | Not disclosed | All 50 states + DC |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #80 | #81 |
Science & Co
74/100Where the value is
- States twice in its footer that "Science and Co, Inc. is not a 503A or 503B compounding facility"
- Its own FAQ names the commitment behind the headline: "Plans start at $79 a month on the 12 month plan"
- The printed saving corroborates the reference price — 79 divided by 149 is 53%, exactly the "Save 47%" shown
The tradeoffs
- The number it leads with is a twelve-month commitment; the per-month rates are $149 and $199
- Only two figures are published per drug, so a three- or six-month plan cannot be priced without starting an intake
PrescrYbe
74/100Where the value is
- Five GLP-1 plans are priced on the weight-loss page before any questionnaire: semaglutide injection $249, tirzepatide injection $339, oral semaglutide $279, and microdose semaglutide or tirzepatide at $179
- Offers an oral semaglutide formulation as well as weekly injections
- Names its clinical partner, OpenLoop Health, and says plans are evaluated by board-certified clinicians, with follow-ups to adjust dosing and manage side effects
The tradeoffs
- Every price is charged per four weeks, not per month, so a year is 13 charges: $3,237 for semaglutide injections rather than 12 × $249
- Cancellations must reach support at least 72 hours before the next billing date, and a cycle that has already been charged is not refunded
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.