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WeighLab

Joi + Blokes vs SkyRx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Joi + Blokes

Provider comparison

Patients already on Joi or Blokes hormone programs who want GLP-1 added under the same clinician relationship, and are comfortable with a 3-month billing commitment.

Semaglutide / month
$179/moBilled quarterly, first month $99, compounded
Tirzepatide / month
$249/moBilled quarterly, first month $149, compounded
Index 56/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Joi + Blokes pricing Read review

SkyRx

Provider comparison

Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.

Semaglutide / month
$199/mo12-month plan paid up front, compounded injection or oral drops; month-to-month price not published
Tirzepatide / month
Not disclosed
Index 55/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check SkyRx pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Joi + Blokes has the higher Cost-Efficiency Index: 56/100 versus 55/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Joi + Blokes

SkyRx

Semaglutide / month
Joi + Blokes: $179/moBilled quarterly, first month $99, compounded
SkyRx: $199/mo12-month plan paid up front, compounded injection or oral drops; month-to-month price not published
Tirzepatide / month
Joi + Blokes: $249/moBilled quarterly, first month $149, compounded
SkyRx: Not disclosed
Semaglutide / year (modeled)
Joi + Blokes: $2,148
SkyRx: $2,388
Tirzepatide / year (modeled)
Joi + Blokes: $2,988
SkyRx: —
State availability
Joi + Blokes: Coverage not published
SkyRx: Coverage not published
Oral / sublingual option listed
Joi + Blokes: Not listed
SkyRx: Yes
Brand-name access listed
Joi + Blokes: Yes
SkyRx: Not confirmed
Provider facts checked
Joi + Blokes: October 2026
SkyRx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Joi + Blokes

Patients already on Joi or Blokes hormone programs who want GLP-1 added under the same clinician relationship, and are comfortable with a 3-month billing commitment.

Reasons to consider it

  • Named Medical Director, Dr. Melissa Loseke, DO, plus a named Head Nurse Practitioner and two named Medical Advisors, more clinical names than most programs we track
  • Separate gender-specific programs (Joi for women, Blokes for men) built around hormone health, with GLP-1 added as an integrated option alongside testosterone/perimenopause protocols
  • For FDA-approved GLP-1/GIP medications specifically, insurance is accepted and the prescription routes to the patient's own local pharmacy rather than a mail-order compounder

What to weigh up

  • Billed in 3-month blocks, not month-to-month — the $99/$149 first-month price is promotional, and the standing cost from month 2 is $179 (semaglutide) or $249 (tirzepatide)
  • New York and New Jersey residents are explicitly called out as paying different pricing, but the site does not state the amount
  • No full state-availability list is published — the safety page only says 'available in certain locations'

Regulatory note: the FDA issued a warning letter to Joi and Blokes dba Joi + Blokes in June 2026. We still list and link to Joi + Blokes; you should know the letter is on the public record before you decide.

Compounded drugs are not FDA-approved. Understand the medication options.

Check Joi + Blokes pricing Read the full Joi + Blokes review

SkyRx

Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.

Reasons to consider it

  • Semaglutide comes as a weekly injection or daily oral drops
  • The price includes the medication, supplies, doctor visit and shipping
  • A written weight-loss guarantee: a refund of the first four months of medication costs if you don't lose 10% in 16 weeks, under its terms

What to weigh up

  • The '$199/mo' price is a 12-month plan paid in full up front, and no month-to-month price is published
  • Tirzepatide is listed as 'coming soon'
  • No medical director or named compounding pharmacy, and no state list

Compounded drugs are not FDA-approved. Understand the medication options.

Check SkyRx pricing Read the full SkyRx review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Joi + BlokesSkyRx
Normalized Cost/Month
Joi + Blokes:
52/100
SkyRx:
51/100
Price Transparency
Joi + Blokes:
78/100
SkyRx:
86/100
Nationwide Access
Joi + Blokes:
24/100
SkyRx:
24/100
Formulation Options
Joi + Blokes:
79/100
SkyRx:
64/100
Clinical Oversight
Joi + Blokes:
82/100
SkyRx:
76/100
Contract Flexibility
Joi + Blokes:
20/100
SkyRx:
20/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.