Alternatives
Alternatives to Nucific
Nucific scores 66/100 on our Cost-Efficiency Index . Here are other programs to consider, each scored the same way. Partners are listed first.
Nucific at a glance
- Semaglutide
- $117/moLowest advertised price; plan length and dose not stated, compounded
- Tirzepatide
- $139/moLowest advertised price; plan length and dose not stated, compounded
- Coverage
- Coverage not published
- Brand-name GLP-1s
- Yes
- Oral option
- No
- Pricing verified
- October 2026
2 of the 8 programs below list semaglutide for less than Nucific's $117 a month. 0 of the 8 list tirzepatide for less than its $139 a month.
Nucific, a supplement brand, also runs a prescription GLP-1 program through OpenLoop Health's licensed providers, with compounded semaglutide from $117 a month, tirzepatide from $139, and brand-name Ozempic and Zepbound.
Best for: Shoppers who want low advertised prices on compounded semaglutide or tirzepatide, with medication, labs and provider visits in one price and no membership fee.
What Nucific does well
- Publishes prices up front: compounded semaglutide from $117 a month and tirzepatide from $139, plus lower-dose microdose plans and brand-name Ozempic and Zepbound
- The treatment price includes the medication, required labs and provider consultations, with no membership fee
- Prescribing is done by OpenLoop Health's network of U.S.-licensed providers
- You can cancel at any time to stop future billing
Why readers look for an alternative
- The 'as low as' prices don't say which plan length or dose they belong to, and the sign-up discount applies to the first payment only
- Fees aren't refunded if you cancel mid-cycle, and you must cancel at least 72 hours before your next billing date
- Doesn't name its pharmacies or list the states it serves; its founder, Dr. Amy Lee, MD, is named, but no medical director for the prescribing network is
- The same storefront sells over-the-counter supplements, so make sure you're buying the prescription program
- Partner01A94/ 100Index
CoreAge Rx
CoreAge Rx charges one flat price at every dose, $99 a month for semaglutide and $149 for tirzepatide, with no membership fee.
- Sema
- $99/mo
- Tirz
- $149/mo
- Coverage
- All 50 states
- Brand
- Compounded
Compared with Nucific: $18/mo less for semaglutide · $10/mo more for tirzepatide · compounded only, no brand-name GLP-1s
- 02C66/ 100Index
Cielo
Cielo is a compounded-GLP-1 telehealth service with one price at every dose: $139 a month for semaglutide and $189 for tirzepatide on the monthly plan, and less on 3-, 6- and 12-month plans.
- Sema
- $139/moAll doses, monthly plan, compounded; $99/mo on a 3-month plan, $89/mo on 6 months, $84/mo on 12 months
- Tirz
- $189/moAll doses, monthly plan, compounded; $149/mo on a 3-month plan, $129/mo on 6 months, $119/mo on 12 months
- Coverage
- Multi-state
- Brand
- Compounded
Compared with Nucific: $22/mo more for semaglutide · $50/mo more for tirzepatide · compounded only, no brand-name GLP-1s
- 03C66/ 100Index
Factor Health MD
Factor Health MD is a compounded-GLP-1 and general telehealth clinic (LegitScript-certified per its footer badge, based in St. Petersburg, FL) offering semaglutide and tirzepatide.
- Sema
- $99.99/moAll doses, monthly plan with a 3-month minimum, compounded; $79.99/mo on a 12-month plan
- Tirz
- $189.99/moAll doses, monthly plan with a 3-month minimum, compounded; $149.99/mo on a 12-month plan
- Coverage
- Multi-state
- Brand
- Compounded
Compared with Nucific: $17.01/mo less for semaglutide · $50.99/mo more for tirzepatide · compounded only, no brand-name GLP-1s
- 04C66/ 100Index
Peptivo
Peptivo is a well-documented telehealth GLP-1 and peptide-wellness platform with four named compounding pharmacies, a named Chief Medical Innovation Officer and pharmacy-operations VP, nationwide 50-state shipping.
- Sema
- $179/moCompounded medication, consultation, shipping and support included
- Tirz
- $279/moCompounded medication, consultation, shipping and support included
- Coverage
- Multi-state
- Brand
- Yes
Compared with Nucific: $62/mo more for semaglutide · $140/mo more for tirzepatide
- 05C66/ 100Index
Southern Vitality and Weight Loss
Southern Vitality offers Valdosta clinic visits and telehealth with Dr. Igor Ancor. One-month compounded packages cost $199 semaglutide or $299 tirzepatide; longer prepaid packages and fixed-payment plans are also listed.
- Sema
- $199/moCompounded
- Tirz
- $299/moCompounded
- Coverage
- Multi-state
- Brand
- Compounded
Compared with Nucific: $82/mo more for semaglutide · $160/mo more for tirzepatide · compounded only, no brand-name GLP-1s
- 06C66/ 100Index
LeanDose
LeanDose is a compounded-GLP-1 telehealth service with a named compounding pharmacy partner (Striker Pharmacy) and a real LegitScript certification, serving a specific 17-state list.
- Sema
- $159For the first month (starting dose, compounded; refill price not published)
- Tirz
- $279For the first month (starting dose, compounded; refill price not published)
- Coverage
- Multi-state
- Brand
- Compounded
Compared with Nucific: $42/mo more for semaglutide · $140/mo more for tirzepatide · compounded only, no brand-name GLP-1s
- 07C66/ 100Index
Klarity Health
Klarity connects patients with independent weight-management providers across all 50 states, including clinicians who prescribe branded GLP-1s. Visit fees and pharmacy medication costs are separate.
- Sema
- Not disclosed
- Tirz
- Not disclosed
- Coverage
- All 50 states
- Brand
- Yes
- 08C66/ 100Index
QuickMD
QuickMD charges $99 for a phone or video weight-loss consultation, with branded medication prescribed only when appropriate and paid separately at your chosen pharmacy. Oral Rybelsus is among its options.
- Sema
- Not disclosed
- Tirz
- Not disclosed
- Coverage
- Multi-state
- Brand
- Yes
Compared with Nucific: offers an oral option
Assume any provider we list may compensate us — it never changes the Cost-Efficiency Index. Pricing and coverage reflect public disclosures at last review; confirm on each provider's site. Not medical advice. See our disclosure.