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WeighLab

Southern Vitality and Weight Loss vs Nucific

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Nucific

Provider comparison

Shoppers who want low advertised prices on compounded semaglutide or tirzepatide, with medication, labs and provider visits in one price and no membership fee.

Semaglutide / month
$117/moLowest advertised price; plan length and dose not stated, compounded
Tirzepatide / month
$139/moLowest advertised price; plan length and dose not stated, compounded
Index 66/100 · Grade CChecked October 2026

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The comparison in brief

Both score 66/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

Check the difference in state access

Southern Vitality and Weight Loss
Telehealth coverage to confirm; no treatment-specific state list
Nucific
Coverage not published

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Southern Vitality and Weight Loss

Nucific

Semaglutide / month
Southern Vitality and Weight Loss: $199/moCompounded
Nucific: $117/moLowest advertised price; plan length and dose not stated, compounded
Tirzepatide / month
Southern Vitality and Weight Loss: $299/moCompounded
Nucific: $139/moLowest advertised price; plan length and dose not stated, compounded
Semaglutide / year (modeled)
Southern Vitality and Weight Loss: $2,388
Nucific: $1,404
Tirzepatide / year (modeled)
Southern Vitality and Weight Loss: $3,588
Nucific: $1,668
State availability
Southern Vitality and Weight Loss: Telehealth coverage to confirm; no treatment-specific state list
Nucific: Coverage not published
Oral / sublingual option listed
Southern Vitality and Weight Loss: Not listed
Nucific: Not listed
Brand-name access listed
Southern Vitality and Weight Loss: Not confirmed
Nucific: Yes
Provider facts checked
Southern Vitality and Weight Loss: October 2026
Nucific: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Southern Vitality and Weight Loss

Readers who want a named physician and named pharmacy partners and will confirm their state and chosen package billing.

Reasons to consider it

  • Names Dr. Igor Ancor as medical director and names its pharmacy partners
  • Publishes $199 semaglutide and $299 tirzepatide one-month packages
  • Medication, supplies, shipping and biweekly check-ins are included

What to weigh up

  • The site does not publish a treatment-specific state list; the doctor being licensed in eleven states does not identify where your prescription can ship
  • The headline says $79 per four weeks on a twelve-month plan, while its FAQ quotes $948 for twelve months; confirm the actual supply length and total
  • Longer packages require prepayment or a committed payment plan

Nucific

Shoppers who want low advertised prices on compounded semaglutide or tirzepatide, with medication, labs and provider visits in one price and no membership fee.

Reasons to consider it

  • Publishes prices up front: compounded semaglutide from $117 a month and tirzepatide from $139, plus lower-dose microdose plans and brand-name Ozempic and Zepbound
  • The treatment price includes the medication, required labs and provider consultations, with no membership fee
  • Prescribing is done by OpenLoop Health's network of U.S.-licensed providers

What to weigh up

  • The 'as low as' prices don't say which plan length or dose they belong to, and the sign-up discount applies to the first payment only
  • Fees aren't refunded if you cancel mid-cycle, and you must cancel at least 72 hours before your next billing date
  • Doesn't name its pharmacies or list the states it serves; its founder, Dr. Amy Lee, MD, is named, but no medical director for the prescribing network is

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Southern Vitality and Weight LossNucific
Normalized Cost/Month
Southern Vitality and Weight Loss:
64/100
Nucific:
80/100
Price Transparency
Southern Vitality and Weight Loss:
92/100
Nucific:
78/100
Nationwide Access
Southern Vitality and Weight Loss:
24/100
Nucific:
24/100
Formulation Options
Southern Vitality and Weight Loss:
66/100
Nucific:
79/100
Clinical Oversight
Southern Vitality and Weight Loss:
92/100
Nucific:
76/100
Contract Flexibility
Southern Vitality and Weight Loss:
61/100
Nucific:
53/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.