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WeighLab

Cielo vs Nucific

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Cielo

Provider comparison

Shoppers who want one price at every dose and can choose between a monthly plan and cheaper 3-, 6- or 12-month plans.

Semaglutide / month
$139/moAll doses, monthly plan, compounded; $99/mo on a 3-month plan, $89/mo on 6 months, $84/mo on 12 months
Tirzepatide / month
$189/moAll doses, monthly plan, compounded; $149/mo on a 3-month plan, $129/mo on 6 months, $119/mo on 12 months
Index 66/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Cielo pricing Read review

Nucific

Provider comparison

Shoppers who want low advertised prices on compounded semaglutide or tirzepatide, with medication, labs and provider visits in one price and no membership fee.

Semaglutide / month
$117/moLowest advertised price; plan length and dose not stated, compounded
Tirzepatide / month
$139/moLowest advertised price; plan length and dose not stated, compounded
Index 66/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Nucific pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Both score 66/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Cielo

Nucific

Semaglutide / month
Cielo: $139/moAll doses, monthly plan, compounded; $99/mo on a 3-month plan, $89/mo on 6 months, $84/mo on 12 months
Nucific: $117/moLowest advertised price; plan length and dose not stated, compounded
Tirzepatide / month
Cielo: $189/moAll doses, monthly plan, compounded; $149/mo on a 3-month plan, $129/mo on 6 months, $119/mo on 12 months
Nucific: $139/moLowest advertised price; plan length and dose not stated, compounded
Semaglutide / year (modeled)
Cielo: $1,668
Nucific: $1,404
Tirzepatide / year (modeled)
Cielo: $2,268
Nucific: $1,668
State availability
Cielo: Coverage not published
Nucific: Coverage not published
Oral / sublingual option listed
Cielo: Not listed
Nucific: Not listed
Brand-name access listed
Cielo: Not confirmed
Nucific: Yes
Provider facts checked
Cielo: October 2026
Nucific: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Cielo

Shoppers who want one price at every dose and can choose between a monthly plan and cheaper 3-, 6- or 12-month plans.

Reasons to consider it

  • Flat pricing regardless of dose for both semaglutide and tirzepatide, avoiding per-mg price escalation during titration
  • Free physician consult and free shipping stated as included
  • Claims 'Every batch tested', at least asserting quality-control testing exists

What to weigh up

  • The 3-, 6- and 12-month plans don't say whether they're paid up front or billed monthly, so ask before you pick one
  • Compounded semaglutide and tirzepatide only, with no brand-name option
  • The site doesn't name its pharmacy, medical director or prescribers

Compounded drugs are not FDA-approved. Understand the medication options.

Check Cielo pricing Read the full Cielo review

Nucific

Shoppers who want low advertised prices on compounded semaglutide or tirzepatide, with medication, labs and provider visits in one price and no membership fee.

Reasons to consider it

  • Publishes prices up front: compounded semaglutide from $117 a month and tirzepatide from $139, plus lower-dose microdose plans and brand-name Ozempic and Zepbound
  • The treatment price includes the medication, required labs and provider consultations, with no membership fee
  • Prescribing is done by OpenLoop Health's network of U.S.-licensed providers

What to weigh up

  • The 'as low as' prices don't say which plan length or dose they belong to, and the sign-up discount applies to the first payment only
  • Fees aren't refunded if you cancel mid-cycle, and you must cancel at least 72 hours before your next billing date
  • Doesn't name its pharmacies or list the states it serves; its founder, Dr. Amy Lee, MD, is named, but no medical director for the prescribing network is

Compounded drugs are not FDA-approved. Understand the medication options.

Check Nucific pricing Read the full Nucific review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

CieloNucific
Normalized Cost/Month
Cielo:
86/100
Nucific:
80/100
Price Transparency
Cielo:
94/100
Nucific:
78/100
Nationwide Access
Cielo:
24/100
Nucific:
24/100
Formulation Options
Cielo:
66/100
Nucific:
79/100
Clinical Oversight
Cielo:
80/100
Nucific:
76/100
Contract Flexibility
Cielo:
25/100
Nucific:
53/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.