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WeighLab

Zera Health vs Open Water Rx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Zera Health

Provider comparison

Shoppers who want a named 503A pharmacy and full 50-state coverage at a moderate compounded price.

Semaglutide / month
$179/moCompounded injection, monthly billing; $149 first month or on a prepaid quarterly plan
Tirzepatide / month
$255/moCompounded injection, monthly billing; $199 first month, $215/mo on a prepaid quarterly plan
Index 79/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Zera Health pricing Read review

Open Water Rx

Provider comparison

Shoppers who want published monthly all-dose injection prices and separate oral options.

Semaglutide / month
$169/moAll doses, monthly compounded injection program
Tirzepatide / month
$219/moAll doses, monthly compounded injection program
Index 78/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Open Water Rx pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Zera Health has the higher Cost-Efficiency Index: 79/100 versus 78/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Zera Health

Open Water Rx

Semaglutide / month
Zera Health: $179/moCompounded injection, monthly billing; $149 first month or on a prepaid quarterly plan
Open Water Rx: $169/moAll doses, monthly compounded injection program
Tirzepatide / month
Zera Health: $255/moCompounded injection, monthly billing; $199 first month, $215/mo on a prepaid quarterly plan
Open Water Rx: $219/moAll doses, monthly compounded injection program
Semaglutide / year (modeled)
Zera Health: $2,148
Open Water Rx: $2,028
Tirzepatide / year (modeled)
Zera Health: $3,060
Open Water Rx: $2,628
State availability
Zera Health: All 50 states
Open Water Rx: All 50 states
Oral / sublingual option listed
Zera Health: Yes
Open Water Rx: Yes
Brand-name access listed
Zera Health: Not confirmed
Open Water Rx: Not confirmed
Provider facts checked
Zera Health: October 2026
Open Water Rx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Zera Health

Shoppers who want a named 503A pharmacy and full 50-state coverage at a moderate compounded price.

Reasons to consider it

  • Named dispensing pharmacy — Strive Pharmacy, a 503A compounder — disclosed in the footer
  • LegitScript Certified badge displayed
  • States coverage across all 50 states with no exclusions listed

What to weigh up

  • First-month, monthly and quarterly prices differ; confirm your plan and second charge before paying
  • Quarterly plans require three months of payment at once
  • No individual prescriber or medical director is named

Compounded drugs are not FDA-approved. Understand the medication options.

Check Zera Health pricing Read the full Zera Health review

Open Water Rx

Shoppers who want published monthly all-dose injection prices and separate oral options.

Reasons to consider it

  • One-month injection plans have no dose-based price increase
  • Clinical review, medication if prescribed, shipping and follow-up are included
  • Oral semaglutide and tirzepatide have separate published prices

What to weigh up

  • Multi-month plans require prepayment; confirm the total before buying
  • Cancel at least 72 hours before the next billing date
  • The homepage says no charge before approval, while its cancellation policy describes payment at checkout and a refund if declined

Compounded drugs are not FDA-approved. Understand the medication options.

Check Open Water Rx pricing Read the full Open Water Rx review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Zera HealthOpen Water Rx
Normalized Cost/Month
Zera Health:
73/100
Open Water Rx:
81/100
Price Transparency
Zera Health:
92/100
Open Water Rx:
94/100
Nationwide Access
Zera Health:
86/100
Open Water Rx:
86/100
Formulation Options
Zera Health:
77/100
Open Water Rx:
77/100
Clinical Oversight
Zera Health:
82/100
Open Water Rx:
59/100
Contract Flexibility
Zera Health:
55/100
Open Water Rx:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.