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WeighLab

SkyRx vs Medi-Weightloss

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

SkyRx

Provider comparison

Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.

Semaglutide / month
$199/mo12-month plan paid up front, compounded injection or oral drops; month-to-month price not published
Tirzepatide / month
Not disclosed
Index 55/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check SkyRx pricing Read review

Medi-Weightloss

Provider comparison

Shoppers near one of Medi-Weightloss's 139 US clinics who want in-person labs and are comfortable with location-dependent pricing.

Semaglutide / month
$99/moStarting dose, first-month rate, plus a separate fee, compounded
Tirzepatide / month
$199/moStarting dose, first-month rate, plus a separate fee, compounded
Index 54/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Medi-Weightloss pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

SkyRx has the higher Cost-Efficiency Index: 55/100 versus 54/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

SkyRx

Medi-Weightloss

Semaglutide / month
SkyRx: $199/mo12-month plan paid up front, compounded injection or oral drops; month-to-month price not published
Medi-Weightloss: $99/moStarting dose, first-month rate, plus a separate fee, compounded
Tirzepatide / month
SkyRx: Not disclosed
Medi-Weightloss: $199/moStarting dose, first-month rate, plus a separate fee, compounded
Semaglutide / year (modeled)
SkyRx: $2,388
Medi-Weightloss: $1,188
Tirzepatide / year (modeled)
SkyRx: —
Medi-Weightloss: $2,388
State availability
SkyRx: Coverage not published
Medi-Weightloss: Coverage not published
Oral / sublingual option listed
SkyRx: Yes
Medi-Weightloss: Not listed
Brand-name access listed
SkyRx: Not confirmed
Medi-Weightloss: Yes
Provider facts checked
SkyRx: October 2026
Medi-Weightloss: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

SkyRx

Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.

Reasons to consider it

  • Semaglutide comes as a weekly injection or daily oral drops
  • The price includes the medication, supplies, doctor visit and shipping
  • A written weight-loss guarantee: a refund of the first four months of medication costs if you don't lose 10% in 16 weeks, under its terms

What to weigh up

  • The '$199/mo' price is a 12-month plan paid in full up front, and no month-to-month price is published
  • Tirzepatide is listed as 'coming soon'
  • No medical director or named compounding pharmacy, and no state list

Compounded drugs are not FDA-approved. Understand the medication options.

Check SkyRx pricing Read the full SkyRx review

Medi-Weightloss

Shoppers near one of Medi-Weightloss's 139 US clinics who want in-person labs and are comfortable with location-dependent pricing.

Reasons to consider it

  • The homepage reports 139 in-person clinic locations across the US, with labs and body composition analysis done at the new-patient visit
  • Publishes real introductory numbers ($99 semaglutide / $199 tirzepatide first month) rather than staying fully opaque
  • Insurance path available for branded Zepbound/Wegovy/Saxenda, with the site claiming most insured patients 'pay between $0 and $50 per visit'

What to weigh up

  • The $99/$199 headline figures are explicitly FIRST-MONTH-ONLY; the ongoing self-pay rate 'varies by program and location' and is never published anywhere on the site
  • A separate $199 new-patient visit fee is charged before the first month's medication price even applies
  • Because each clinic is independently operated, the same program can cost a different amount at two different Medi-Weightloss locations

Compounded drugs are not FDA-approved. Understand the medication options.

Check Medi-Weightloss pricing Read the full Medi-Weightloss review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

SkyRxMedi-Weightloss
Normalized Cost/Month
SkyRx:
51/100
Medi-Weightloss:
71/100
Price Transparency
SkyRx:
86/100
Medi-Weightloss:
20/100
Nationwide Access
SkyRx:
24/100
Medi-Weightloss:
24/100
Formulation Options
SkyRx:
64/100
Medi-Weightloss:
79/100
Clinical Oversight
SkyRx:
76/100
Medi-Weightloss:
87/100
Contract Flexibility
SkyRx:
20/100
Medi-Weightloss:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.