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WeighLab

Rylo Health vs Jyra Health

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Rylo Health

Provider comparison

Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.

Semaglutide / month
$139/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
Tirzepatide / month
$229/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
Index 84/100 · Grade BChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Rylo Health pricing Read review

Jyra Health

Provider comparison

Shoppers who want low compounded GLP-1 pricing and are comfortable prepaying a 3-month plan.

Semaglutide / month
$169/moAll doses, monthly compounded plan
Tirzepatide / month
$229/moAll doses, monthly compounded plan
Index 82/100 · Grade B−Checked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Jyra Health pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Rylo Health has the higher Cost-Efficiency Index: 84/100 versus 82/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Rylo Health

Jyra Health

Semaglutide / month
Rylo Health: $139/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
Jyra Health: $169/moAll doses, monthly compounded plan
Tirzepatide / month
Rylo Health: $229/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
Jyra Health: $229/moAll doses, monthly compounded plan
Semaglutide / year (modeled)
Rylo Health: $1,668
Jyra Health: $2,028
Tirzepatide / year (modeled)
Rylo Health: $2,748
Jyra Health: $2,748
State availability
Rylo Health: All 50 states
Jyra Health: All 50 states
Oral / sublingual option listed
Rylo Health: Not listed
Jyra Health: Not listed
Brand-name access listed
Rylo Health: Not confirmed
Jyra Health: Not confirmed
Provider facts checked
Rylo Health: October 2026
Jyra Health: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Rylo Health

Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.

Reasons to consider it

  • Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
  • Medication, provider review and shipping are all stated as included in the quoted price, with no add-ons listed
  • Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous

What to weigh up

  • The advertised $100/$160 monthly equivalents require $299/$479 paid once per quarter
  • Its product pages say no membership fees, while the terms describe separately billed membership; confirm the complete charge
  • The terms say refunds depend on the treatment stage and describe the full terms as still being finalized

Compounded drugs are not FDA-approved. Understand the medication options.

Check Rylo Health pricing Read the full Rylo Health review

Jyra Health

Shoppers who want low compounded GLP-1 pricing and are comfortable prepaying a 3-month plan.

Reasons to consider it

  • Flat monthly pricing across doses
  • Consultation, medication and shipping included
  • Names VialsRX, White Label Pharmacy and Hallandale

What to weigh up

  • $99 and $133 monthly averages require three months prepaid
  • Individual pharmacy coverage differs by state
  • Ask which pharmacy and formulation will fill your prescription

Compounded drugs are not FDA-approved. Understand the medication options.

Check Jyra Health pricing Read the full Jyra Health review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Rylo HealthJyra Health
Normalized Cost/Month
Rylo Health:
87/100
Jyra Health:
77/100
Price Transparency
Rylo Health:
94/100
Jyra Health:
97/100
Nationwide Access
Rylo Health:
86/100
Jyra Health:
86/100
Formulation Options
Rylo Health:
66/100
Jyra Health:
66/100
Clinical Oversight
Rylo Health:
83/100
Jyra Health:
87/100
Contract Flexibility
Rylo Health:
83/100
Jyra Health:
73/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.