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WeighLab

Rx.com vs SkinnyRx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Rx.com

Provider comparison

Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.

Semaglutide / month
$175/moMonth-to-month; $165 on three months, $146 on six and $99 on twelve, prepaid
Tirzepatide / month
$285/moMonth-to-month; $265 on three months, $259 on six and $149 on twelve, prepaid
Index 77/100 · Grade CChecked October 2026

SkinnyRx

Affiliate partner

Shoppers who want a cheap first month to see how they tolerate a GLP-1, and who will budget for the price from month two.

Semaglutide / month
$249/moMonth to month after a $99 first month ($199/mo on a 12-month plan)
Tirzepatide / month
$299/moMonth to month after a $99 first month ($225/mo on a 12-month plan)
Index 74/100 · Grade CChecked October 2026

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Rx.com has the higher Cost-Efficiency Index: 77/100 versus 74/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Rx.com
47 states on its program page; product pages say 49
SkinnyRx
Most states

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Rx.com

SkinnyRx

Semaglutide / month
Rx.com: $175/moMonth-to-month; $165 on three months, $146 on six and $99 on twelve, prepaid
SkinnyRx: $249/moMonth to month after a $99 first month ($199/mo on a 12-month plan)
Tirzepatide / month
Rx.com: $285/moMonth-to-month; $265 on three months, $259 on six and $149 on twelve, prepaid
SkinnyRx: $299/moMonth to month after a $99 first month ($225/mo on a 12-month plan)
Semaglutide / year (modeled)
Rx.com: $2,100
SkinnyRx: $2,988
Tirzepatide / year (modeled)
Rx.com: $3,420
SkinnyRx: $3,588
State availability
Rx.com: 47 states on its program page; product pages say 49
SkinnyRx: Most states
Oral / sublingual option listed
Rx.com: Not listed
SkinnyRx: Yes
Brand-name access listed
Rx.com: Not confirmed
SkinnyRx: Not confirmed
Provider facts checked
Rx.com: October 2026
SkinnyRx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Rx.com

Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.

Reasons to consider it

  • "No automatic renewals" is printed under the plan card itself rather than buried in the terms
  • Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
  • One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included

What to weigh up

  • The $99/mo semaglutide and $149/mo tirzepatide headlines require a 12-month prepayment of $1,188 or $1,788
  • Its program page excludes Alaska, Louisiana and Mississippi, while product pages exclude only Alaska; confirm coverage before paying
  • Injection only — no oral route and no brand-name lane

SkinnyRx

Shoppers who want a cheap first month to see how they tolerate a GLP-1, and who will budget for the price from month two.

Reasons to consider it

  • The first month of either injection is $99, so trying the medication costs little
  • Prepaid plans lower the price: semaglutide renews at $225 a month on four months, $215 on six and $199 on twelve
  • Both compounded molecules come as a weekly injection or a daily tablet

What to weigh up

  • From month two the injection is $249 for semaglutide or $299 for tirzepatide, well above the $99 you see first
  • An FDA warning letter is on public record against Lean Rx, Inc. dba SkinnyRx, issued February 2026
  • Brand-name drugs appear in its catalog, but the Wegovy pill is listed as unavailable

Regulatory note: the FDA issued a warning letter to Lean Rx, Inc. dba SkinnyRx in February 2026. We still list and link to SkinnyRx; you should know the letter is on the public record before you decide.

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Rx.comSkinnyRx
Normalized Cost/Month
Rx.com:
74/100
SkinnyRx:
71/100
Price Transparency
Rx.com:
76/100
SkinnyRx:
84/100
Nationwide Access
Rx.com:
82/100
SkinnyRx:
82/100
Formulation Options
Rx.com:
62/100
SkinnyRx:
73/100
Clinical Oversight
Rx.com:
78/100
SkinnyRx:
66/100
Contract Flexibility
Rx.com:
96/100
SkinnyRx:
58/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.