Lyfe Rx vs California Trim Clinic

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Lyfe Rx

Provider comparison

Shoppers who want one all-inclusive price with no separate membership, and the option to buy a single month without subscribing.

Semaglutide / month: $225.50/moMonthly subscription, compounded; $275 as a one-time order, $206.25/mo billed every 3 months
Tirzepatide / month: $327.18/moMonthly subscription, compounded; $399 as a one-time order, $299.25/mo billed every 3 months

Index 68/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Lyfe Rx pricing Read review

California Trim Clinic

Provider comparison

Shoppers who want compounded semaglutide or tirzepatide paid order by order, with no membership or auto-renewal, and don't mind a discovery call first.

Semaglutide / month: $199/moStarting price; higher-dose prices not published, compounded
Tirzepatide / month: $299/moStarting price; higher-dose prices not published, compounded

Index 68/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check California Trim Clinic pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Both score 68/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

Check the difference in state access

Lyfe Rx: 49 states
California Trim Clinic: All 50 states

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Lyfe Rx

California Trim Clinic

Semaglutide / month: Lyfe Rx: $225.50/moMonthly subscription, compounded; $275 as a one-time order, $206.25/mo billed every 3 months; California Trim Clinic: $199/moStarting price; higher-dose prices not published, compounded

Tirzepatide / month: Lyfe Rx: $327.18/moMonthly subscription, compounded; $399 as a one-time order, $299.25/mo billed every 3 months; California Trim Clinic: $299/moStarting price; higher-dose prices not published, compounded

Semaglutide / year (modeled): Lyfe Rx: $2,706; California Trim Clinic: $2,388

Tirzepatide / year (modeled): Lyfe Rx: $3,926; California Trim Clinic: $3,588

State availability: Lyfe Rx: 49 states; California Trim Clinic: All 50 states

Oral / sublingual option listed: Lyfe Rx: Not listed; California Trim Clinic: Not listed

Brand-name access listed: Lyfe Rx: Not confirmed; California Trim Clinic: Not confirmed

Provider facts checked: Lyfe Rx: October 2026; California Trim Clinic: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Lyfe Rx

Shoppers who want one all-inclusive price with no separate membership, and the option to buy a single month without subscribing.

Reasons to consider it

All-inclusive pricing with no membership: the listed price covers the provider review, medication, supplies and free shipping
Buy one month at a time, or subscribe for 18% off monthly or 25% off every 3 months, and pause or stop whenever you want
Ships to 49 states (all but Alabama)

What to weigh up

No dose is shown on either listing, so you can't tell what the price buys at higher doses
No compounding pharmacy is named beyond a U.S.-licensed 503A pharmacy
Its pricing page says no consultation charge is added, but the refund policy keeps a $50 intake and doctor fee if you cancel before the prescription is filled

Regulatory note: the FDA issued a warning letter to Lyfe Rx in September 2025. We still list and link to Lyfe Rx; you should know the letter is on the public record before you decide.

Compounded drugs are not FDA-approved. Understand the medication options.

Check Lyfe Rx pricing Read the full Lyfe Rx review

California Trim Clinic

Shoppers who want compounded semaglutide or tirzepatide paid order by order, with no membership or auto-renewal, and don't mind a discovery call first.

Reasons to consider it

Publishes starting prices: compounded semaglutide from $199 a month and tirzepatide from $299
No membership fee and no automatic renewal, so you're charged only when you order
Serves all 50 states by telemedicine, with a physical clinic in Westlake Village, California

What to weigh up

The prices are 'starting at' figures, and the clinic doesn't publish what you'll pay as your dose rises
Doesn't name the providers or a medical director for its adult program, or the pharmacy that fills your prescription
A discovery call is required before you can order medication

Compounded drugs are not FDA-approved. Understand the medication options.

Check California Trim Clinic pricing Read the full California Trim Clinic review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Lyfe RxCalifornia Trim Clinic

Normalized Cost/Month: Lyfe Rx:
53/100; California Trim Clinic:
55/100

Price Transparency: Lyfe Rx:
86/100; California Trim Clinic:
78/100

Nationwide Access: Lyfe Rx:
78/100; California Trim Clinic:
86/100

Formulation Options: Lyfe Rx:
66/100; California Trim Clinic:
66/100

Clinical Oversight: Lyfe Rx:
67/100; California Trim Clinic:
76/100

Contract Flexibility: Lyfe Rx:
55/100; California Trim Clinic:
41/100

Before you sign up

Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.