Head-to-head · Cost-Efficiency Index
CoreAge Rx vs Lyfe Rx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
CoreAge Rx
Anyone optimizing for real value — a transparent flat price you can model for a full year, nationwide, without a bait-and-switch.
Visit CoreAge RxLyfe Rx
Shoppers who want one flat all-inclusive charge with no separate membership fee, in 49 states.
Visit Lyfe RxThe verdict
CoreAge Rx takes it, leading the Cost-Efficiency Index 94 to 52. Best value in the ranking: both molecules at one flat, all-50 price with no teaser step-ups — the lowest true cost of ownership, not the lowest teaser. Lyfe Rx still earns a C — Shoppers who want one flat all-inclusive charge with no separate membership fee, in 49 states.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | CoreAge Rx | Lyfe Rx |
|---|---|---|
| Cost-Efficiency Index | 94/100 | 52/100 |
| Semaglutide / mo | $99/mo | $225/mo (plus a separate fee, compounded) |
| Tirzepatide / mo | $149/mo | $299/mo (plus a separate fee, compounded) |
| Semaglutide / yr (modeled) | $1,188 | $2,700 |
| Tirzepatide / yr (modeled) | $1,788 | $3,588 |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #1 | #389 |
CoreAge Rx
94/100Where the value is
- Flat all-in monthly price — no intro rate that silently triples after month one, so the modeled annual cost is the real cost
- Both compounded semaglutide and tirzepatide on one account at published prices
- Available in all 50 states — no coverage gamble
The tradeoffs
- Not the rock-bottom sticker price — 30 of the 381 priced semaglutide programs we track list a cheaper figure, though most attach a term or a step-up that CoreAge does not
- No FDA-approved brand-name option (compounded only)
Lyfe Rx
52/100Where the value is
- Genuinely all-inclusive flat pricing — 'Every price covers your provider review, your medication, all medical supplies and free shipping,' with no separate membership charge unlike several competitors in this category
- 49-state coverage explicitly disclosed ('throughout the United States with the exception of Alabama')
- LegitScript Certified badge with a verification link displayed on the homepage
The tradeoffs
- No dose (mg) is shown on the semaglutide or tirzepatide product listing, so a shopper cannot tell what starting dose $225/$299 actually buys before starting the intake
- No compounding pharmacy is named beyond generic '503A pharmacy' language, and no medical director or prescriber is named anywhere on the site
Regulatory note: the FDA issued a warning letter to Lyfe Rx in September 2025. We still list and link to Lyfe Rx; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.