Head-to-head · Cost-Efficiency Index
LillyDirect Foundayo vs Wisp
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
LillyDirect Foundayo
Patients who want an FDA-approved, manufacturer-direct oral GLP-1 rather than a compounded injectable.
Visit LillyDirect FoundayoWisp
Cost-first shoppers who want branded injectables plus a sublingual semaglutide alternative.
Visit WispThe verdict
LillyDirect Foundayo and Wisp tie on the Cost-Efficiency Index at 63/100, so neither wins outright on the numbers. For most shoppers we'd start with LillyDirect Foundayo (ranked #196, a hair above #202) — Patients who want an FDA-approved, manufacturer-direct oral GLP-1 rather than a compounded injectable. But Wisp is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs LillyDirect Foundayo.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | LillyDirect Foundayo | Wisp |
|---|---|---|
| Cost-Efficiency Index | 63/100 | 63/100 |
| Semaglutide / mo | Not disclosed | $225/mo (compounded oral) |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | — | $2,700 |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | All 50 states | Coverage not published |
| Oral / sublingual | Yes | Yes |
| Brand-name access | Yes | Yes |
| Rank here | #196 | #202 |
LillyDirect Foundayo
63/100Where the value is
- First-party Eli Lilly program -- highest possible manufacturer authenticity
- FDA-approved branded drug (orforglipron), not an unapproved compounded formulation
- Published self-pay starting price ($149) via savings card
The tradeoffs
- Not semaglutide or tirzepatide -- a different molecule (orforglipron), so not directly comparable on this list
- The $149 price is tied to a specific Savings Card program with its own terms, not an unconditional list price
Wisp
63/100Where the value is
- Broad GLP-1 menu — branded injectables (Wegovy, Zepbound, Saxenda) plus a compounded sublingual option
- LegitScript certified with named board-certified providers (Dr. Shannon Chatham DO, Andrea Sleeth WHNP-BC)
- Unusually candid about the sublingual option's limits, noting effectiveness in patients may vary
The tradeoffs
- The $99/mo tirzepatide figure is a consultation-and-care subscription, not the medication: Zepbound is filled at a pharmacy of your choice at its own cost, which Wisp does not publish
- The compounded semaglutide option is sublingual drops, which Wisp itself describes as less effective than injection
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.