Head-to-head · Cost-Efficiency Index
Jyra Health vs PrescrYbe
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Jyra Health
Shoppers who want low compounded GLP-1 pricing and are comfortable prepaying a 3-month plan.
Visit Jyra HealthPrescrYbe
Shoppers who want an injection, an oral tablet or a microdose plan priced up front on one page, and who budget by the four-week cycle rather than the month.
Visit PrescrYbeThe verdict
Jyra Health and PrescrYbe tie on the Cost-Efficiency Index at 74/100, so neither wins outright on the numbers, so choose on fit. Jyra Health: Shoppers who want low compounded GLP-1 pricing and are comfortable prepaying a 3-month plan. PrescrYbe: Shoppers who want an injection, an oral tablet or a microdose plan priced up front on one page, and who budget by the four-week cycle rather than the month.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Jyra Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Jyra Health | PrescrYbe |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 74/100 |
| Semaglutide / mo | $175/moAll doses, compounded | $249Every 4 weeks (compounded injection; oral $279, microdose $179) |
| Tirzepatide / mo | $199/moAll doses, compounded | $339Every 4 weeks (compounded injection; microdose $179) |
| Semaglutide / yr (modeled) | $2,100 | $3,23713 charges |
| Tirzepatide / yr (modeled) | $2,388 | $4,40713 charges |
| Coverage | All 50 states | All 50 states + DC |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #77 | #81 |
Jyra Health
74/100Where the value is
- Genuine, math-consistent 3-month prepay discount ($111 off semaglutide, $60 off tirzepatide across 3 months) rather than a vague 'up to X% off' claim
- Flat price at every dose with no renewal increase, on both the 1-month and 3-month tiers
- Claims all-50-state coverage with no membership fees and free express delivery
The tradeoffs
- The lower headline-friendly prices ($139/mo semaglutide, $179/mo tirzepatide) are only available by prepaying a full 3-month plan up front, not as a standing month-to-month rate
- No compounding pharmacy is named anywhere on the site
PrescrYbe
74/100Where the value is
- Five GLP-1 plans are priced on the weight-loss page before any questionnaire: semaglutide injection $249, tirzepatide injection $339, oral semaglutide $279, and microdose semaglutide or tirzepatide at $179
- Offers an oral semaglutide formulation as well as weekly injections
- Names its clinical partner, OpenLoop Health, and says plans are evaluated by board-certified clinicians, with follow-ups to adjust dosing and manage side effects
The tradeoffs
- Every price is charged per four weeks, not per month, so a year is 13 charges: $3,237 for semaglutide injections rather than 12 × $249
- Cancellations must reach support at least 72 hours before the next billing date, and a cycle that has already been charged is not refunded
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.