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Head-to-head · Cost-Efficiency Index

CaliberRx vs LillyDirect Foundayo

Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.

Better valueGrade C · #189

CaliberRx

Shoppers who want simple flat-rate pricing and a clear, published list of excluded states.

Visit CaliberRx
VS
Grade C · #196

LillyDirect Foundayo

Patients who want an FDA-approved, manufacturer-direct oral GLP-1 rather than a compounded injectable.

Visit LillyDirect Foundayo

The verdict

Too close to callGrade C vs C

CaliberRx and LillyDirect Foundayo tie on the Cost-Efficiency Index at 63/100, so neither wins outright on the numbers. For most shoppers we'd start with CaliberRx (ranked #189, a hair above #196) — Shoppers who want simple flat-rate pricing and a clear, published list of excluded states. But LillyDirect Foundayo is a genuine coin-flip alternative here.

Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs CaliberRx.

Factor by factor

Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.

Normalized Cost/Month

57
45

Price Transparency

94
54

Nationwide Access

24
86

Formulation Options

66
69

Clinical Oversight

88
76

Contract Flexibility

47
55

Pricing, coverage & formulary

The disclosed facts behind the scores. Lower price wins its row (teal).

SpecCaliberRxLillyDirect Foundayo
Cost-Efficiency Index63/10063/100
Semaglutide / mo$199/mo (all doses, compounded)Not disclosed
Tirzepatide / mo$199/mo (all doses, compounded)Not disclosed
Semaglutide / yr (modeled)$2,388
Tirzepatide / yr (modeled)$2,388
CoverageCoverage not publishedAll 50 states
Oral / sublingualNoYes
Brand-name accessCompounded onlyYes
Rank here#189#196

CaliberRx

63/100

Where the value is

  • Flat, identical $199/month pricing for both semaglutide and tirzepatide -- no confusing dose tiers to compare
  • No prepay or first-month-only trap detected on the pages checked
  • LegitScript certification verifiably linked

The tradeoffs

  • No individual medical director named
  • No compounding pharmacy named
Visit CaliberRx

Full CaliberRx review →

LillyDirect Foundayo

63/100

Where the value is

  • First-party Eli Lilly program -- highest possible manufacturer authenticity
  • FDA-approved branded drug (orforglipron), not an unapproved compounded formulation
  • Published self-pay starting price ($149) via savings card

The tradeoffs

  • Not semaglutide or tirzepatide -- a different molecule (orforglipron), so not directly comparable on this list
  • The $149 price is tied to a specific Savings Card program with its own terms, not an unconditional list price
Visit LillyDirect Foundayo

Full LillyDirect Foundayo review →

Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.

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