Head-to-head · Cost-Efficiency Index
ZYP Medical vs MediRX
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
ZYP Medical
Cost-first shoppers who want men in IA, NE, SD, MN, KS, CO or AZ wanting a low starter rate with an oral needle-free option.
Visit ZYP MedicalMediRX
Shoppers who want transparent published pricing and don't mind that prescribing is handled by a third-party clinician network (OpenLoop) rather than an in-house medical team.
Visit MediRXThe verdict
ZYP Medical takes it, leading the Cost-Efficiency Index 56 to 55. ZYP Medical is a men's-health-oriented telehealth practice now covering seven Midwest/Mountain states (recently adding Minnesota) with both injectable and oral (ODT) tirzepatide. MediRX still earns a C — Shoppers who want transparent published pricing and don't mind that prescribing is handled by a third-party clinician network (OpenLoop) rather than an in-house medical team.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs ZYP Medical.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | ZYP Medical | MediRX |
|---|---|---|
| Cost-Efficiency Index | 56/100 | 55/100 |
| Semaglutide / mo | $150/mo (starting dose, 3 month plan, plus a separate fee, compounded) | $149/mo (starting dose, compounded) |
| Tirzepatide / mo | $233/mo (starting dose, 3 month plan, plus a separate fee, compounded) | $199/mo (starting dose, compounded) |
| Semaglutide / yr (modeled) | $1,800 | $1,788 |
| Tirzepatide / yr (modeled) | $2,796 | $2,388 |
| Coverage | 6 states | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #333 | #339 |
ZYP Medical
56/100Where the value is
- Offers a genuine needle-free oral tirzepatide (ODT) option, not just injectable
- Consult fee is disclosed and itemized ($50, or $29.99 for a shorter returning-patient visit)
- Recently expanded to 7 states (added Minnesota)
The tradeoffs
- Advertised $150/$233 prices are explicitly labeled 'starter plans (initial 3 months)' — what they become after 3 months is not published anywhere on the site
- One-time consult fee ($29.99-$50) is charged on top of the medication price and is non-refundable once the visit occurs
MediRX
55/100Where the value is
- Publishes specific dollar pricing for both injection and oral-tablet forms of both drugs
- Rare self-disclosed distinction between promotional ($149) and standard ($179) semaglutide pricing
- LegitScript badge displayed on the page
The tradeoffs
- MediRx itself has no named medical director -- all clinical care is outsourced to OpenLoop Health's network
- Tirzepatide's wide $199-$399 range makes the true likely monthly cost at a therapeutic dose unclear
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.