Head-to-head · Cost-Efficiency Index
Yes Clinic vs Enhanced
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Yes Clinic
Shoppers who can pay for three months at once and want a price that won't rise as their dose goes up.
Visit Yes ClinicEnhanced
Shoppers who want a low starting price on compounded semaglutide or tirzepatide and are comfortable confirming the dose-level price after checkout.
Visit EnhancedThe verdict
Yes Clinic and Enhanced tie on the Cost-Efficiency Index at 65/100, so neither wins outright on the numbers, so choose on fit. Yes Clinic: Shoppers who can pay for three months at once and want a price that won't rise as their dose goes up. Enhanced: Shoppers who want a low starting price on compounded semaglutide or tirzepatide and are comfortable confirming the dose-level price after checkout.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Yes Clinic.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Yes Clinic | Enhanced |
|---|---|---|
| Cost-Efficiency Index | 65/100 | 65/100 |
| Semaglutide / mo | $129/mo3-month plan, billed $387 upfront, same price at every dose, compounded | $89/moStarting price, compounded |
| Tirzepatide / mo | $149/mo3-month plan, billed $447 upfront, same price at every dose, compounded | $129/moStarting price, compounded |
| Semaglutide / yr (modeled) | $1,548 | $1,068 |
| Tirzepatide / yr (modeled) | $1,788 | $1,548 |
| Coverage | Not published | Not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #211 | #213 |
Yes Clinic
65/100Where the value is
- Every plan price is on the product pages with no quiz or account: semaglutide $387 for 3 months or $699 for 6, tirzepatide $447 or $894
- The price stays the same at every dose, and the online consultation, shipping and membership are all included at $0
- If a provider declines to prescribe, you aren't charged for medication, and a 6-month plan refunds months 4 to 6 if they aren't approved
The tradeoffs
- There is no single-month plan: the cheapest way in is three months paid upfront
- The homepage says GLP-1 programs start "From $199/month" and mentions monthly plan rates, while the product pages show only $129 and $149 a month on 3- and 6-month plans
Enhanced
65/100Where the value is
- Starting prices are on the product pages before checkout: semaglutide from $89 a month, tirzepatide from $129
- The monthly price includes the medication, clinician review and follow-ups
- Microdose plans start at $59 a month for semaglutide and $79 for tirzepatide
The tradeoffs
- Both prices are "starting at" figures, and the price at higher doses isn't published
- No list of the states it serves; its terms point to the partner telehealth platform for that
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.