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WeighLab

Trillium Meds vs Open Water Rx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Trillium Meds

Provider comparison

Shoppers who want compounded GLP-1 in all 50 states with a real month-to-month option and a cheaper 3-month prepay.

Semaglutide / month
$159/moAll doses, compounded
Tirzepatide / month
$199/moAny dose, compounded; pharmacy-specific plans
Index 78/100 · Grade CChecked October 2026

Open Water Rx

Provider comparison

Shoppers who want published monthly all-dose injection prices and separate oral options.

Semaglutide / month
$169/moAll doses, monthly compounded injection program
Tirzepatide / month
$219/moAll doses, monthly compounded injection program
Index 78/100 · Grade CChecked October 2026

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The comparison in brief

Both score 78/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Trillium Meds

Open Water Rx

Semaglutide / month
Trillium Meds: $159/moAll doses, compounded
Open Water Rx: $169/moAll doses, monthly compounded injection program
Tirzepatide / month
Trillium Meds: $199/moAny dose, compounded; pharmacy-specific plans
Open Water Rx: $219/moAll doses, monthly compounded injection program
Semaglutide / year (modeled)
Trillium Meds: $1,908
Open Water Rx: $2,028
Tirzepatide / year (modeled)
Trillium Meds: $2,388
Open Water Rx: $2,628
State availability
Trillium Meds: All 50 states
Open Water Rx: All 50 states
Oral / sublingual option listed
Trillium Meds: Not listed
Open Water Rx: Yes
Brand-name access listed
Trillium Meds: Not confirmed
Open Water Rx: Not confirmed
Provider facts checked
Trillium Meds: October 2026
Open Water Rx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Trillium Meds

Shoppers who want compounded GLP-1 in all 50 states with a real month-to-month option and a cheaper 3-month prepay.

Reasons to consider it

  • Names pharmacy partners and displays their plan totals, formulations and shipping restrictions
  • One-month and prepaid options are published before intake
  • One-month semaglutide $159 and tirzepatide $199 offers cover any prescribed dose at several pharmacies

What to weigh up

  • Lower prepaid averages require buying multiple months at once; plans and state restrictions differ by pharmacy
  • The pharmacy card and actual fulfillment pharmacy can differ; Hyalo lists NewLife and Nova lists White Label as fulfillment partners
  • Pharmacy choice depends on availability and can be changed by the provider or pharmacy

Open Water Rx

Shoppers who want published monthly all-dose injection prices and separate oral options.

Reasons to consider it

  • One-month injection plans have no dose-based price increase
  • Clinical review, medication if prescribed, shipping and follow-up are included
  • Oral semaglutide and tirzepatide have separate published prices

What to weigh up

  • Multi-month plans require prepayment; confirm the total before buying
  • Cancel at least 72 hours before the next billing date
  • The homepage says no charge before approval, while its cancellation policy describes payment at checkout and a refund if declined

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Trillium MedsOpen Water Rx
Normalized Cost/Month
Trillium Meds:
80/100
Open Water Rx:
81/100
Price Transparency
Trillium Meds:
97/100
Open Water Rx:
94/100
Nationwide Access
Trillium Meds:
86/100
Open Water Rx:
86/100
Formulation Options
Trillium Meds:
66/100
Open Water Rx:
77/100
Clinical Oversight
Trillium Meds:
89/100
Open Water Rx:
59/100
Contract Flexibility
Trillium Meds:
25/100
Open Water Rx:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.