Synergy Rx vs PlexusDx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Synergy Rx

Provider comparison

Readers comparing injection, dissolving-tablet and brand-name routes who will confirm the plan total and billing schedule.

Semaglutide / month: $199Starting price (compounded injection; billing cycle and dose not stated)
Tirzepatide / month: $349Starting price (compounded injection; billing cycle and dose not stated)

Index 79/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Synergy Rx pricing Read review

PlexusDx

Provider comparison

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Semaglutide / month: $189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan
Tirzepatide / month: $289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan

Index 79/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Both score 79/100 on the Cost-Efficiency Index. There is no score winner; compare the treatment you need, billing terms and state availability.

Check the difference in state access

Synergy Rx: All 50 states claimed in FAQ; subject to provider availability
PlexusDx: All 50 states

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Synergy Rx

PlexusDx

Semaglutide / month: Synergy Rx: $199Starting price (compounded injection; billing cycle and dose not stated); PlexusDx: $189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan

Tirzepatide / month: Synergy Rx: $349Starting price (compounded injection; billing cycle and dose not stated); PlexusDx: $289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan

Semaglutide / year (modeled): Synergy Rx: $2,388; PlexusDx: $2,268

Tirzepatide / year (modeled): Synergy Rx: $4,188; PlexusDx: $3,468

State availability: Synergy Rx: All 50 states claimed in FAQ; subject to provider availability; PlexusDx: All 50 states

Oral / sublingual option listed: Synergy Rx: Yes; PlexusDx: Yes

Brand-name access listed: Synergy Rx: Yes; PlexusDx: Not confirmed

Provider facts checked: Synergy Rx: October 2026; PlexusDx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Synergy Rx

Readers comparing injection, dissolving-tablet and brand-name routes who will confirm the plan total and billing schedule.

Reasons to consider it

Offers compounded injections, compounded oral dissolving tablets and brand-name Wegovy, Mounjaro and Ozempic
Lists starting prices before consultation
FAQ says all 50 states, subject to state rules and licensed-provider availability

What to weigh up

Starting figures do not specify the billing cycle or dose; confirm the complete plan total
Oral semaglutide starts at $299 and oral tirzepatide at $399, above the injection floors
State availability is conditional; confirm that a licensed provider can treat you

Compounded drugs are not FDA-approved. Understand the medication options.

Check Synergy Rx pricing Read the full Synergy Rx review

PlexusDx

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Reasons to consider it

LegitScript Certified, with the seal on the homepage
Same price at every dose, with no membership: semaglutide $189 and tirzepatide $289 month to month, less on 3- and 6-month plans
Both molecules come as weekly injections or daily tablets

What to weigh up

The 'starts at' $149 and $249 figures are 6-month-plan prices; month to month, semaglutide is $189 and tirzepatide $289
The tablets cost more than the shots: oral semaglutide starts at $249/mo and oral tirzepatide at $279/mo on the 6-month plan
No named prescriber, medical director, or specific compounding pharmacy

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read the full PlexusDx review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Synergy RxPlexusDx

Normalized Cost/Month: Synergy Rx:
74/100; PlexusDx:
76/100

Price Transparency: Synergy Rx:
65/100; PlexusDx:
94/100

Nationwide Access: Synergy Rx:
88/100; PlexusDx:
86/100

Formulation Options: Synergy Rx:
95/100; PlexusDx:
77/100

Clinical Oversight: Synergy Rx:
90/100; PlexusDx:
74/100

Contract Flexibility: Synergy Rx:
68/100; PlexusDx:
55/100

Before you sign up

Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.