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Best-value alternatives

Alternatives to Synergy Rx

Synergy Rx scores 71/100 on our Cost-Efficiency Index (ranked #31 of 31). Here are the top-ranked programs worth weighing against it — scored the same way.

Read the Synergy Rx review →CoreAge Rx vs Synergy Rx →
  1. Our #1 pick
    01A

    CoreAge Rx

    Ranked #1

    Best value on the board: both molecules at one flat, all-50 price with no teaser step-ups — the lowest true cost of ownership, not the lowest teaser.

    Sema
    $149/mo
    Tirz
    $349/mo
    Coverage
    All 50 states
    Brand
    Compounded
    Visit CoreAge Rx CoreAge Rx vs Synergy Rx →
  2. 02B+

    Invigor Medical

    Ranked #2

    Solid mid-market cost on both molecules from an established operator — good value if you also want a broader metabolic and hormone catalog.

    Sema
    $199/mo
    Tirz
    $339/mo
    Coverage
    Not disclosed
    Brand
    Compounded
    Visit Invigor Medical Invigor Medical vs Synergy Rx →
  3. 03A−

    Ondra Health

    Ranked #3

    A rare combination — near-rock-bottom pricing on both molecules, all-50 access, brand-name availability, and a LegitScript-verified pharmacy behind it.

    Sema
    $93/mo
    Tirz
    $166/mo
    Coverage
    All 50 states
    Brand
    Yes
    Visit Ondra Health Ondra Health vs Synergy Rx →
  4. 04B+

    ShedRx (Shed)

    Ranked #4

    The widest set of formats on the board — injection, drops, lozenges and a daily oral pill, plus a real brand Zepbound route — though its cheapest advertised rates need a year-long commitment.

    Sema
    $199/mo ($159 on a 12-month plan)
    Tirz
    $299/mo ($239 on a 12-month plan)
    Coverage
    All 50 states
    Brand
    Yes
    Visit ShedRx (Shed) ShedRx (Shed) vs Synergy Rx →
  5. 05B+

    Strut Health

    Ranked #5

    The lowest true entry cost on this board — $99/month sublingual semaglutide — and the only place selling the same molecule as a lozenge or an injection at one price.

    Sema
    From $99/mo sublingual, $149/mo injectable
    Tirz
    From $199/mo either route
    Coverage
    Multi-state
    Brand
    Compounded
    Visit Strut Health Strut Health vs Synergy Rx →
  6. 06B

    Breeze Meds

    Ranked #6

    The most transparent operator in our partner tier — all-50 compounded GLP-1 with NPI-verifiable named physicians, named pharmacies and LegitScript backing, so you can actually audit who's behind the script.

    Sema
    $199/mo
    Tirz
    $399/mo
    Coverage
    All 50 states
    Brand
    Compounded
    Visit Breeze Meds Breeze Meds vs Synergy Rx →
  7. 07B

    Sesame Care

    Ranked #7

    The widest real brand-name GLP-1 access on the board — a LegitScript- and BBB-recognized national marketplace running since 2018 that dispenses FDA-approved Wegovy, Zepbound, Ozempic, Mounjaro and Rybelsus, not compounded copies.

    Sema
    $149/mo (brand)
    Tirz
    Brand (Zepbound)
    Coverage
    Nationwide
    Brand
    Yes
    Visit Sesame Care Sesame Care vs Synergy Rx →
  8. 08B

    Eden

    Ranked #8

    You pay a premium per month, but you buy back certainty: all-50 access and high-disclosure clinical oversight that hold their value.

    Sema
    $239/mo
    Tirz
    $349/mo
    Coverage
    All 50 states
    Brand
    Compounded
    Visit Eden Eden vs Synergy Rx →

Assume any provider we list may compensate us — it never changes the Cost-Efficiency Index. Pricing and coverage reflect public disclosures at last review; confirm on each provider's site. Not medical advice. See our disclosure.

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