Head-to-head · Cost-Efficiency Index
Synergy Rx vs Jyra Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Synergy Rx
People who want a genuine brand-name route and maximum clinician access, and will accept getting a quote by inquiry.
Visit Synergy RxJyra Health
Cost-first shoppers who want low compounded GLP-1 pricing if you're comfortable prepaying a 3-month plan.
Visit Jyra HealthThe verdict
Jyra Health takes it, leading the Cost-Efficiency Index 74 to 72. Jyra Health is a compounded GLP-1 telehealth clinic charging $175/mo (semaglutide) or $199/mo (tirzepatide) month-to-month, discounted to $139/mo and $179/mo respectively on a 3-month prepaid plan. Synergy Rx still earns a C — People who want a genuine brand-name route and maximum clinician access, and will accept getting a quote by inquiry.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Jyra Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Synergy Rx | Jyra Health |
|---|---|---|
| Cost-Efficiency Index | 72/100 | 74/100 |
| Semaglutide / mo | From $199/mo | $175/mo (all doses, compounded) |
| Tirzepatide / mo | From $349/mo | $199/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | $2,388 | $2,100 |
| Tirzepatide / yr (modeled) | $4,188 | $2,388 |
| Coverage | Not disclosed | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #53 | #59 |
Synergy Rx
72/100Where the value is
- Prescribes FDA-approved brand Wegovy, Ozempic and Mounjaro when clinically appropriate, not compounded only
- Unlimited appointments, unlimited messaging and 24/7 access to a dedicated clinical team
- A $100 welcome credit applied at checkout, and FSA/HSA eligible
The tradeoffs
- Prices are published as bare “Starting at” figures with no billing cycle or term attached, so a full-year cost still cannot be modeled before an inquiry
- At $349/mo tirzepatide sits roughly $100 above the compounded median we track
Jyra Health
74/100Where the value is
- Genuine, math-consistent 3-month prepay discount ($111 off semaglutide, $60 off tirzepatide across 3 months) rather than a vague 'up to X% off' claim
- Flat price at every dose with no renewal increase, on both the 1-month and 3-month tiers
- Claims all-50-state coverage with no membership fees and free express delivery
The tradeoffs
- The lower headline-friendly prices ($139/mo semaglutide, $179/mo tirzepatide) are only available by prepaying a full 3-month plan up front, not as a standing month-to-month rate
- No compounding pharmacy is named anywhere on the site
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.