Head-to-head · Cost-Efficiency Index
SynergenX Health vs Framework
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
SynergenX Health
Cost-first shoppers who want men and women already seeking in-person TRT/HRT care who might add GLP-1s as a secondary service -- not a fit for GLP-1-first shoppers.
Visit SynergenX HealthFramework
Cost-first shoppers who want doctor-guided treatment selection with a named pharmacy, if you can accept learning the price only after intake.
Visit FrameworkThe verdict
SynergenX Health takes it, leading the Cost-Efficiency Index 46 to 45. SynergenX is primarily a 64-location, 10-state in-person TRT (testosterone) and HRT clinic chain, not a GLP-1-first telehealth company. Framework still earns a C — Cost-first shoppers who want doctor-guided treatment selection with a named pharmacy, if you can accept learning the price only after intake.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs SynergenX Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | SynergenX Health | Framework |
|---|---|---|
| Cost-Efficiency Index | 46/100 | 45/100 |
| Semaglutide / mo | Not disclosed | Not disclosed |
| Tirzepatide / mo | Not disclosed | Not disclosed |
| Semaglutide / yr (modeled) | — | — |
| Tirzepatide / yr (modeled) | — | — |
| Coverage | 10 states | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #461 | #463 |
SynergenX Health
46/100Where the value is
- Large in-person clinic footprint (64 locations, 10 states) for patients who prefer face-to-face visits
- Established, multi-service hormone-therapy brand
- One transparent price point exists for hormone lab testing ($99 self-pay)
The tradeoffs
- No GLP-1/semaglutide/tirzepatide pricing published anywhere on the site
- Primarily a TRT/HRT business; weight loss and GLP-1s are an undifferentiated add-on, not a core offering
Framework
45/100Where the value is
- The compounding pharmacy partner is named, which most of this field does not do
- Treatment selection is doctor-guided rather than a fixed product menu
- US-licensed clinicians and a 503A pharmacy pathway
The tradeoffs
- No monthly medication price is published: the tirzepatide and semaglutide pages carry no price at all, and the homepage advertises a per-week figure for 'GLP-1s' generally rather than a rate for either drug
- The only drug-specific prices anywhere on the site sit on a legacy page — semaglutide at $349 per three months and tirzepatide at $549 per three months
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.