Head-to-head · Cost-Efficiency Index
Science & Co vs He & She MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Science & Co
A twelve-month committer, or someone who values a company stating plainly what it is and is not.
Visit Science & CoHe & She MD
Shoppers comparing injectable semaglutide specifically, where the advertised $199 genuinely is the standing price — not oral semaglutide or tirzepatide, which roll higher after 6 months.
Visit He & She MDThe verdict
Science & Co takes it, leading the Cost-Efficiency Index 74 to 71. Declares in its own footer that it is not a compounding facility, and explains its own asterisk in its own FAQ — two disclosures most of this market never makes. He & She MD still earns a C — Shoppers comparing injectable semaglutide specifically, where the advertised $199 genuinely is the standing price — not oral semaglutide or tirzepatide, which roll higher after 6 months.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Science & Co.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Science & Co | He & She MD |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 71/100 |
| Semaglutide / mo | $149/mo month-to-month; $79 only on a twelve-month plan | $199/mo (month to month, compounded; every lower rate is a prepaid term) |
| Tirzepatide / mo | $199/mo month-to-month; $125 only on a twelve-month plan | $299/mo (month to month, compounded; every lower rate is a prepaid term) |
| Semaglutide / yr (modeled) | $1,788 | $2,388 |
| Tirzepatide / yr (modeled) | $2,388 | $2,388 |
| Coverage | Not disclosed | All states except Louisiana (GLP-1) |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #62 | #65 |
Science & Co
74/100Where the value is
- States twice in its footer that "Science and Co, Inc. is not a 503A or 503B compounding facility"
- Its own FAQ names the commitment behind the headline: "Plans start at $79 a month on the 12 month plan"
- The printed saving corroborates the reference price — 79 divided by 149 is 53%, exactly the "Save 47%" shown
The tradeoffs
- The number it leads with is a twelve-month commitment; the per-month rates are $149 and $199
- Only two figures are published per drug, so a three- or six-month plan cannot be priced without starting an intake
He & She MD
71/100Where the value is
- Compounded semaglutide and tirzepatide (injectable or oral), with brand-name access to Ozempic, Wegovy, and Zepbound also offered
- Named pharmacy (F&F Pharmacies Inc DBA Jungle Jim's Pharmacy, Fairfield OH) and named CMO (Dr. Ozita Cooper, MD)
- Free expedited shipping and unlimited board-certified clinician access
The tradeoffs
- Its own FAQ says the pharmacy it names holds a license in 44 US states, none in California, Nevada, New Jersey, North Carolina, Texas, Massachusetts, Mississippi, New Hampshire, West Virginia or Delaware, and “cannot dispense sterile compounds” — while the same FAQ says GLP-1s ship everywhere except Louisiana. Injectable GLP-1s are sterile compounds, and the site never says which of its two pharmacies covers the gap
- The uniform '$199 to start' banner across all three tracks obscures that only injectable semaglutide holds at $199 ongoing — oral semaglutide rolls to $239/mo and injectable tirzepatide rolls to $289/mo after the first 6-month cycle
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.