Head-to-head · Cost-Efficiency Index
Science & Co vs Amazon One Medical
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Science & Co
A twelve-month committer, or someone who values a company stating plainly what it is and is not.
Visit Science & CoAmazon One Medical
Patients who specifically want a real FDA-approved branded medication (Wegovy, Zepbound, or Foundayo) rather than a compounded alternative, and already shop on Amazon.
Visit Amazon One MedicalThe verdict
Science & Co takes it, leading the Cost-Efficiency Index 74 to 73. Declares in its own footer that it is not a compounding facility, and explains its own asterisk in its own FAQ — two disclosures most of this market never makes. Amazon One Medical still earns a C — Patients who specifically want a real FDA-approved branded medication (Wegovy, Zepbound, or Foundayo) rather than a compounded alternative, and already shop on Amazon.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Science & Co.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Science & Co | Amazon One Medical |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 73/100 |
| Semaglutide / mo | $149/mo month-to-month; $79 only on a twelve-month plan | $299/mo (brand Wegovy, plus a separate fee) |
| Tirzepatide / mo | $199/mo month-to-month; $125 only on a twelve-month plan | $299/mo (brand Zepbound) |
| Semaglutide / yr (modeled) | $1,788 | $3,588 |
| Tirzepatide / yr (modeled) | $2,388 | $3,588 |
| Coverage | Not disclosed | All 50 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Yes |
| Rank here | #62 | #67 |
Science & Co
74/100Where the value is
- States twice in its footer that "Science and Co, Inc. is not a 503A or 503B compounding facility"
- Its own FAQ names the commitment behind the headline: "Plans start at $79 a month on the 12 month plan"
- The printed saving corroborates the reference price — 79 divided by 149 is 53%, exactly the "Save 47%" shown
The tradeoffs
- The number it leads with is a twelve-month commitment; the per-month rates are $149 and $199
- Only two figures are published per drug, so a three- or six-month plan cannot be priced without starting an intake
Amazon One Medical
73/100Where the value is
- Prescribes only FDA-approved branded medications — no compounded product risk, which in this ranking only LillyDirect also avoids
- Same-day medication delivery available in roughly 3,000 cities via Amazon Pharmacy's existing logistics network
- One Medical membership is explicitly optional, not a gate, to access GLP-1 care
The tradeoffs
- The care fee (~$39-$49) and the medication cost are billed completely separately — the site itself warns 'the cost of your prescribed medication is not included with the treatment price,' so no single headline number captures the real all-in cost
- The lowest advertised Rx price ('$149 with coupon if eligible') is conditional on manufacturer coupon eligibility, not guaranteed to every patient
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.