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WeighLab

Rylo Health vs OrderlyMeds

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Rylo Health

Provider comparison

Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.

Semaglutide / month
$139/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
Tirzepatide / month
$229/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
Index 84/100 · Grade BChecked October 2026

OrderlyMeds

Provider comparison

Patients comparing the regular monthly price with prepaid starter offers and included care.

Semaglutide / month
$149/moStanding all-dose compounded rate; lower two-month introductory offers
Tirzepatide / month
$299/moCompounded
Index 83/100 · Grade BChecked October 2026

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Rylo Health has the higher Cost-Efficiency Index: 84/100 versus 83/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Rylo Health
All 50 states
OrderlyMeds
All 50 states (per FAQ)

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Rylo Health

OrderlyMeds

Semaglutide / month
Rylo Health: $139/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
OrderlyMeds: $149/moStanding all-dose compounded rate; lower two-month introductory offers
Tirzepatide / month
Rylo Health: $229/moAll doses, monthly plan; lower rates with quarterly prepayment, compounded
OrderlyMeds: $299/moCompounded
Semaglutide / year (modeled)
Rylo Health: $1,668
OrderlyMeds: $1,788
Tirzepatide / year (modeled)
Rylo Health: $2,748
OrderlyMeds: $3,588
State availability
Rylo Health: All 50 states
OrderlyMeds: All 50 states (per FAQ)
Oral / sublingual option listed
Rylo Health: Not listed
OrderlyMeds: Not listed
Brand-name access listed
Rylo Health: Not confirmed
OrderlyMeds: Yes
Provider facts checked
Rylo Health: October 2026
OrderlyMeds: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Rylo Health

Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.

Reasons to consider it

  • Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
  • Medication, provider review and shipping are all stated as included in the quoted price, with no add-ons listed
  • Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous

What to weigh up

  • The advertised $100/$160 monthly equivalents require $299/$479 paid once per quarter
  • Its product pages say no membership fees, while the terms describe separately billed membership; confirm the complete charge
  • The terms say refunds depend on the treatment stage and describe the full terms as still being finalized

OrderlyMeds

Patients comparing the regular monthly price with prepaid starter offers and included care.

Reasons to consider it

  • Regular monthly rates are $149 semaglutide and $299 tirzepatide
  • Publishes the full two-month starter and special-offer totals
  • Names PerfectRx/PerfectionRx, ProRx, Casa, Pharmacy Hub and SmartPharmaRx

What to weigh up

  • The $74/$149 introductory equivalents require a two-month purchase and new-customer eligibility
  • The FAQ and pricing page describe starter availability differently; confirm the selected plan
  • Brand-name Wegovy and Zepbound are listed at substantially higher retail prices

Regulatory note: the FDA issued a warning letter to OrderlyMeds LLC dba OrderlyMeds in June 2026. We still list and link to OrderlyMeds; you should know the letter is on the public record before you decide.

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Rylo HealthOrderlyMeds
Normalized Cost/Month
Rylo Health:
87/100
OrderlyMeds:
89/100
Price Transparency
Rylo Health:
94/100
OrderlyMeds:
97/100
Nationwide Access
Rylo Health:
86/100
OrderlyMeds:
86/100
Formulation Options
Rylo Health:
66/100
OrderlyMeds:
79/100
Clinical Oversight
Rylo Health:
83/100
OrderlyMeds:
75/100
Contract Flexibility
Rylo Health:
83/100
OrderlyMeds:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.