Head-to-head · Cost-Efficiency Index
RxPepsDirect vs Fifty 410
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
RxPepsDirect
Cost-first shoppers who want the all-in per-order cost of a compounded GLP-1 with no subscription, in 28 states.
Visit RxPepsDirectFifty 410
Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Visit Fifty 410The verdict
RxPepsDirect takes it, leading the Cost-Efficiency Index 60 to 59. RxPepsDirect (Peptide RX LLC) is a per-vial compounded GLP-1 telehealth platform whose advertised vial prices are not the whole cost: a flat medical visit charge and flat overnight delivery are added to every order. Fifty 410 still earns a C — Cost-first shoppers who want a one-time-payment compounded tirzepatide bundle, understanding the 'per month' figure is really a 3-month lump sum.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs RxPepsDirect.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | RxPepsDirect | Fifty 410 |
|---|---|---|
| Cost-Efficiency Index | 60/100 | 59/100 |
| Semaglutide / mo | $79/mo (starting dose, visit fee and shipping included, compounded) | $199/mo (all doses, compounded) |
| Tirzepatide / mo | $99/mo (starting dose, visit fee and shipping included, compounded) | $133/mo (starting dose, 3-month plan, compounded) |
| Semaglutide / yr (modeled) | $948 | $2,388 |
| Tirzepatide / yr (modeled) | $1,188 | $1,596 |
| Coverage | 28 states | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #256 | #263 |
RxPepsDirect
60/100Where the value is
- Every component of the price is published on the site — the vial tiers, the flat visit charge and the flat overnight delivery — so the all-in monthly cost can be worked out before ordering
- No subscription and no commitment: you pay per order, and one visit charge covers up to three peptides on the same prescription
- Real 503A telehealth Rx — licensed NP/PA prescribers under medical director Dr. Jonathan Snipes (NPI 1821250077), dispensed by Optimal Balance Pharmacy, Texas Ranking #34829
The tradeoffs
- The advertised vial price is not the monthly cost: a flat $39 medical visit charge and $15 flat FedEx shipping land on every order, and the visit charge recurs on every reorder rather than once
- Higher doses need more than one vial a month and the site publishes no price for the dose you titrate up to, so the figure above is a floor
Fifty 410
59/100Where the value is
- No recurring subscription — you pay once per order and are not auto-billed
- Transparent per-tier tirzepatide totals ($399/$499/$549) shown alongside the per-month math, so the real charge is visible if you read past the headline
- Free overnight/2-day shipping and refrigerated packaging included in every tier
The tradeoffs
- Tirzepatide's advertised '$133/month' is a 3-month prepay of $399 charged in one transaction, not a monthly recurring price — the cheapest advertised number is not what most shoppers will assume
- Semaglutide has no discounted multi-month tier and, at $199 flat, actually costs more per month than tirzepatide's cheapest bundle
Regulatory note: the FDA issued a warning letter to Aspen Aesthetics dba Fifty 410 in February 2026. We still list and link to Fifty 410; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.