Head-to-head · Cost-Efficiency Index
Rx.com vs Rylo Health
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Rx.com
Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.
Visit Rx.comRylo Health
Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Visit Rylo HealthThe verdict
Rx.com takes it, leading the Cost-Efficiency Index 77 to 75. Prints "No automatic renewals" on the plan card and names the pharmacy that dispenses, with a street address — then advertises another drug's prepay rate. Rylo Health still earns a C — Shoppers who want one flat all-in monthly rate that doesn't rise as the dose increases.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Rx.com.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Rx.com | Rylo Health |
|---|---|---|
| Cost-Efficiency Index | 77/100 | 75/100 |
| Semaglutide / mo | $175/mo month-to-month; $165 on three months and $146 on six | $149/mo (all doses, promotional rate, compounded) |
| Tirzepatide / mo | $285/mo month-to-month; $265 on three months and $259 on six | $249/mo (all doses, compounded) |
| Semaglutide / yr (modeled) | $2,100 | $1,788 |
| Tirzepatide / yr (modeled) | $3,420 | $2,988 |
| Coverage | 49 states on its plan page; its own banner says all 50 | All 50 states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #45 | #52 |
Rx.com
77/100Where the value is
- "No automatic renewals" is printed under the plan card itself rather than buried in the terms
- Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
- One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included
The tradeoffs
- The advertised "$146/mo FOR LIFE" is a six-month prepay on semaglutide; month-to-month tirzepatide is $285
- The plan page says 49 states served while the banner on the same site says all 50
Rylo Health
75/100Where the value is
- Stated flat pricing regardless of dose — 'No surprise charges, no tiered pricing' — a genuine differentiator versus tiered competitors
- Medication, provider review, and shipping all stated as included in the quoted price with no add-ons found
- Names its physician group (Lone Star Virtual Health PLLC) and dispensing pharmacy (VialsRX, Houston TX) rather than leaving both anonymous
The tradeoffs
- The '$100/$160 First 20 rate' shown prominently on the homepage is limited to the first 20 signups only — most shoppers will pay the higher $149/$249 standard rate, and the promo framing can make the real price look lower than it is
- The advertised 'quarterly $349/$499' option's actual billing mechanics (one-time total vs. recurring monthly-under-commitment) could not be verified — the product pages that would clarify this render via JavaScript and returned no readable pricing text
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.