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WeighLab

Rx.com vs 50 Stars Health

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Rx.com

Provider comparison

Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.

Semaglutide / month
$175/moMonth-to-month; $165 on three months, $146 on six and $99 on twelve, prepaid
Tirzepatide / month
$285/moMonth-to-month; $265 on three months, $259 on six and $149 on twelve, prepaid
Index 77/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Rx.com pricing Read review

50 Stars Health

Provider comparison

Shoppers who want a flat price that doesn't rise as the dose goes up, and who live in one of its 44 states.

Semaglutide / month
$146/moAll doses, month-to-month, compounded; $133/mo on a 3-month plan, $124/mo on a 6-month plan
Tirzepatide / month
$220/moAll doses, month-to-month, compounded; $201/mo on a 3-month plan, $183/mo on a 6-month plan
Index 76/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check 50 Stars Health pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Rx.com has the higher Cost-Efficiency Index: 77/100 versus 76/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Rx.com
47 states on its program page; product pages say 49
50 Stars Health
44 states + PR (not AL, AR, CA, IN, SC, WV)

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Rx.com

50 Stars Health

Semaglutide / month
Rx.com: $175/moMonth-to-month; $165 on three months, $146 on six and $99 on twelve, prepaid
50 Stars Health: $146/moAll doses, month-to-month, compounded; $133/mo on a 3-month plan, $124/mo on a 6-month plan
Tirzepatide / month
Rx.com: $285/moMonth-to-month; $265 on three months, $259 on six and $149 on twelve, prepaid
50 Stars Health: $220/moAll doses, month-to-month, compounded; $201/mo on a 3-month plan, $183/mo on a 6-month plan
Semaglutide / year (modeled)
Rx.com: $2,100
50 Stars Health: $1,752
Tirzepatide / year (modeled)
Rx.com: $3,420
50 Stars Health: $2,640
State availability
Rx.com: 47 states on its program page; product pages say 49
50 Stars Health: 44 states + PR (not AL, AR, CA, IN, SC, WV)
Oral / sublingual option listed
Rx.com: Not listed
50 Stars Health: Not listed
Brand-name access listed
Rx.com: Not confirmed
50 Stars Health: Not confirmed
Provider facts checked
Rx.com: October 2026
50 Stars Health: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Rx.com

Someone who will judge it by the plan card rather than the banner, and who values no auto-renewal and a named pharmacy over the lowest sticker.

Reasons to consider it

  • "No automatic renewals" is printed under the plan card itself rather than buried in the terms
  • Names Manifest Pharmacy in Greer, South Carolina with a full street address, and MD Integrations as the provider network, on the same page as the price
  • One flat price at every dose from 2.5 mg to 15 mg, with the provider visit, injection supplies and cold shipping stated as included

What to weigh up

  • The $99/mo semaglutide and $149/mo tirzepatide headlines require a 12-month prepayment of $1,188 or $1,788
  • Its program page excludes Alaska, Louisiana and Mississippi, while product pages exclude only Alaska; confirm coverage before paying
  • Injection only — no oral route and no brand-name lane

Compounded drugs are not FDA-approved. Understand the medication options.

Check Rx.com pricing Read the full Rx.com review

50 Stars Health

Shoppers who want a flat price that doesn't rise as the dose goes up, and who live in one of its 44 states.

Reasons to consider it

  • Same price at every dose, with the consultation, follow-ups, supplies and shipping included
  • Month-to-month, 3-month and 6-month plans are all priced on the product pages
  • Publishes its state list for GLP-1s

What to weigh up

  • Not available in Alabama, Arkansas, California, Indiana, South Carolina or West Virginia
  • No compounding pharmacy or medical director is named
  • Subscriptions renew automatically, and refunds are not typically offered once a plan is billed

Compounded drugs are not FDA-approved. Understand the medication options.

Check 50 Stars Health pricing Read the full 50 Stars Health review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Rx.com50 Stars Health
Normalized Cost/Month
Rx.com:
74/100
50 Stars Health:
87/100
Price Transparency
Rx.com:
76/100
50 Stars Health:
94/100
Nationwide Access
Rx.com:
82/100
50 Stars Health:
66/100
Formulation Options
Rx.com:
62/100
50 Stars Health:
66/100
Clinical Oversight
Rx.com:
78/100
50 Stars Health:
79/100
Contract Flexibility
Rx.com:
96/100
50 Stars Health:
49/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.