PlexusDx vs Enhance MD

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

PlexusDx

Provider comparison

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Semaglutide / month: $189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan
Tirzepatide / month: $289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan

Index 79/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read review

Enhance MD

Affiliate partner

Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.

Semaglutide / month: $212/moFirst month $112
Tirzepatide / month: $280/moFirst month $180

Index 76/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Enhance MD pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

PlexusDx has the higher Cost-Efficiency Index: 79/100 versus 76/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

PlexusDx: All 50 states
Enhance MD: 40 states + DC

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

PlexusDx

Enhance MD

Semaglutide / month: PlexusDx: $189/moSame price at every dose, month to month, compounded, all-inclusive; $169/mo on a 3-month plan, $149/mo on a 6-month plan; Enhance MD: $212/moFirst month $112

Tirzepatide / month: PlexusDx: $289/moSame price at every dose, month to month, compounded, all-inclusive; $269/mo on a 3-month plan, $249/mo on a 6-month plan; Enhance MD: $280/moFirst month $180

Semaglutide / year (modeled): PlexusDx: $2,268; Enhance MD: $2,544

Tirzepatide / year (modeled): PlexusDx: $3,468; Enhance MD: $3,360

State availability: PlexusDx: All 50 states; Enhance MD: 40 states + DC

Oral / sublingual option listed: PlexusDx: Yes; Enhance MD: Not listed

Brand-name access listed: PlexusDx: Not confirmed; Enhance MD: Not confirmed

Provider facts checked: PlexusDx: October 2026; Enhance MD: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

PlexusDx

Shoppers who want one price at every dose, an oral option for either molecule, and all 50 states.

Reasons to consider it

LegitScript Certified, with the seal on the homepage
Same price at every dose, with no membership: semaglutide $189 and tirzepatide $289 month to month, less on 3- and 6-month plans
Both molecules come as weekly injections or daily tablets

What to weigh up

The 'starts at' $149 and $249 figures are 6-month-plan prices; month to month, semaglutide is $189 and tirzepatide $289
The tablets cost more than the shots: oral semaglutide starts at $249/mo and oral tirzepatide at $279/mo on the 6-month plan
No named prescriber, medical director, or specific compounding pharmacy

Compounded drugs are not FDA-approved. Understand the medication options.

Check PlexusDx pricing Read the full PlexusDx review

Enhance MD

Shoppers who want flat pricing that doesn't rise with the dose, routine lab monitoring and a semaglutide-plus-tirzepatide combo option, and who don't need a brand-name or oral route.

Reasons to consider it

Every plan is priced on the homepage before any quiz: semaglutide $212, tirzepatide $280, a semaglutide-plus-tirzepatide combo $322 and microdosed tirzepatide $169
The monthly price stays the same as your dose goes up
Lab testing every six months and ongoing provider messaging are built into the price rather than sold separately

What to weigh up

Compounded only, with no brand-name Wegovy, Ozempic, Mounjaro or Zepbound
No oral or sublingual GLP-1, so every option is an injection
The $112 and $180 on the homepage are first-month prices; from month two you pay $212 and $280

Compounded drugs are not FDA-approved. Understand the medication options.

Check Enhance MD pricing Read the full Enhance MD review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

PlexusDxEnhance MD

Normalized Cost/Month: PlexusDx:
76/100; Enhance MD:
65/100

Price Transparency: PlexusDx:
94/100; Enhance MD:
88/100

Nationwide Access: PlexusDx:
86/100; Enhance MD:
66/100

Formulation Options: PlexusDx:
77/100; Enhance MD:
74/100

Clinical Oversight: PlexusDx:
74/100; Enhance MD:
85/100

Contract Flexibility: PlexusDx:
55/100; Enhance MD:
82/100

Before you sign up

Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.