Head-to-head · Cost-Efficiency Index
CoreAge Rx vs Enhance MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
CoreAge Rx
Anyone optimizing for real value — a transparent flat price you can model for a full year, nationwide, without a bait-and-switch.
Visit CoreAge RxEnhance MD
Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Visit Enhance MDThe verdict
CoreAge Rx takes it, leading the Cost-Efficiency Index 94 to 75. Best value on the board: both molecules at one flat, all-50 price with no teaser step-ups — the lowest true cost of ownership, not the lowest teaser. Enhance MD still earns a C — Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | CoreAge Rx | Enhance MD |
|---|---|---|
| Cost-Efficiency Index | 94/100 | 75/100 |
| Semaglutide / mo | $149/mo | $212/mo (first month $112) |
| Tirzepatide / mo | $349/mo | $280/mo (first month $180) |
| Semaglutide / yr (modeled) | $1,788 | $2,544 |
| Tirzepatide / yr (modeled) | $4,188 | $3,360 |
| Coverage | All 50 states | Not disclosed |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank on the board | #1 | #36 |
CoreAge Rx
94/100Where the value is
- Flat all-in monthly price — no intro rate that silently triples after month one, so the modeled annual cost is the real cost
- Both compounded semaglutide and tirzepatide on one account at published prices
- Available in all 50 states — no coverage gamble
The tradeoffs
- Not the rock-bottom sticker price — cheaper teaser tiers exist (Direct GLP lists $65, Ondra $93 on semaglutide)
- No FDA-approved brand-name option (compounded only)
Enhance MD
75/100Where the value is
- Fully published, dose-flat tiered pricing — sema $212/mo, tirz $280/mo, microdose $169/mo, sema+tirz combo $322/mo — no quiz or quote wall
- The rate does not climb as your dose is titrated up, unlike per-mg pricing elsewhere on this board
- Routine lab work at the 6-month mark plus ongoing provider messaging is bundled into the price, not sold separately
The tradeoffs
- Compounded only — no FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- No oral or sublingual GLP-1 option (injection only)
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.