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WeighLab

Open Water Rx vs OnlyRx

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Open Water Rx

Provider comparison

Shoppers who want published monthly all-dose injection prices and separate oral options.

Semaglutide / month
$169/moAll doses, monthly compounded injection program
Tirzepatide / month
$219/moAll doses, monthly compounded injection program
Index 78/100 · Grade CChecked October 2026

OnlyRx

Provider comparison

Shoppers who want a 50-state marketplace with multiple pharmacy options and named prescribers.

Semaglutide / month
$179/moStarting dose, compounded
Tirzepatide / month
$249/moStarting dose, compounded
Index 77/100 · Grade CChecked October 2026

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Open Water Rx has the higher Cost-Efficiency Index: 78/100 versus 77/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Open Water Rx

OnlyRx

Semaglutide / month
Open Water Rx: $169/moAll doses, monthly compounded injection program
OnlyRx: $179/moStarting dose, compounded
Tirzepatide / month
Open Water Rx: $219/moAll doses, monthly compounded injection program
OnlyRx: $249/moStarting dose, compounded
Semaglutide / year (modeled)
Open Water Rx: $2,028
OnlyRx: $2,148
Tirzepatide / year (modeled)
Open Water Rx: $2,628
OnlyRx: $2,988
State availability
Open Water Rx: All 50 states
OnlyRx: All 50 states
Oral / sublingual option listed
Open Water Rx: Yes
OnlyRx: Yes
Brand-name access listed
Open Water Rx: Not confirmed
OnlyRx: Yes
Provider facts checked
Open Water Rx: October 2026
OnlyRx: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Open Water Rx

Shoppers who want published monthly all-dose injection prices and separate oral options.

Reasons to consider it

  • One-month injection plans have no dose-based price increase
  • Clinical review, medication if prescribed, shipping and follow-up are included
  • Oral semaglutide and tirzepatide have separate published prices

What to weigh up

  • Multi-month plans require prepayment; confirm the total before buying
  • Cancel at least 72 hours before the next billing date
  • The homepage says no charge before approval, while its cancellation policy describes payment at checkout and a refund if declined

OnlyRx

Shoppers who want a 50-state marketplace with multiple pharmacy options and named prescribers.

Reasons to consider it

  • Says it serves all 50 states
  • Names physicians at Lion MD with public NPI numbers
  • Lists four pharmacy partners with contact information

What to weigh up

  • The banner still calls $179 a Summer Promo, while product cards say starting at; confirm the ongoing rate
  • No dose-by-dose price list is published
  • Ask which of the four pharmacy partners will fill your prescription

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Open Water RxOnlyRx
Normalized Cost/Month
Open Water Rx:
81/100
OnlyRx:
68/100
Price Transparency
Open Water Rx:
94/100
OnlyRx:
84/100
Nationwide Access
Open Water Rx:
86/100
OnlyRx:
86/100
Formulation Options
Open Water Rx:
77/100
OnlyRx:
90/100
Clinical Oversight
Open Water Rx:
59/100
OnlyRx:
72/100
Contract Flexibility
Open Water Rx:
55/100
OnlyRx:
55/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

Keep comparing

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.