Head-to-head · Cost-Efficiency Index
Open Water Rx vs Joi + Blokes
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Open Water Rx
Cost-first shoppers who want all-inclusive compounded GLP-1 pricing from four named 503A pharmacies, if you qualify for the promo codes.
Visit Open Water RxJoi + Blokes
Patients already on Joi or Blokes hormone programs who want GLP-1 added under the same clinician relationship, and are comfortable with a 3-month billing commitment.
Visit Joi + BlokesThe verdict
Open Water Rx takes it, leading the Cost-Efficiency Index 53 to 52. Open Water Rx is a self-pay telehealth platform selling compounded semaglutide ($199/mo standing, $159/mo with a promo code), tirzepatide ($339/mo standing, $219/mo with a different promo code), and an oral GLP-1 option. Joi + Blokes still earns a C — Patients already on Joi or Blokes hormone programs who want GLP-1 added under the same clinician relationship, and are comfortable with a 3-month billing commitment.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Open Water Rx.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Open Water Rx | Joi + Blokes |
|---|---|---|
| Cost-Efficiency Index | 53/100 | 52/100 |
| Semaglutide / mo | $199/mo (promotional rate, plus a separate fee, compounded) | $199/mo (quarterly plan, compounded) |
| Tirzepatide / mo | $339/mo (compounded) | $299/mo (quarterly plan, compounded) |
| Semaglutide / yr (modeled) | $2,388 | $2,388 |
| Tirzepatide / yr (modeled) | $4,068 | $3,588 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | Yes | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #379 | #384 |
Open Water Rx
53/100Where the value is
- Names four specific 503A compounding pharmacies (RedRock, HealthWarehouse, Precision Compounding, Triad Rx) — most competitors disclose zero
- Pricing is genuinely all-inclusive — clinician review, medication, and shipping bundled with no separate visit fee
- LegitScript certification seals displayed
The tradeoffs
- The lower, more prominent $159/$219 figures depend on promo codes (SEMASUMMER, FOUNDER) stacked on top of stated $199/$339 standing prices — unclear whether these codes are permanent
- A '12-Week Plan' at $169/month strongly implies a multi-month prepay requirement, but the page never states the actual upfront total
Joi + Blokes
52/100Where the value is
- Named Medical Director, Dr. Melissa Loseke, DO, plus a named Head Nurse Practitioner and two named Medical Advisors — real clinical attribution not disclosed by most competitors in this batch
- Separate gender-specific programs (Joi for women, Blokes for men) built around hormone health, with GLP-1 added as an integrated option alongside testosterone/perimenopause protocols
- For FDA-approved GLP-1/GIP medications specifically, insurance is accepted and the prescription routes to the patient's own local pharmacy rather than a mail-order compounder
The tradeoffs
- Billed in 3-month blocks, not month-to-month — the $99/$149 first-month price is promotional, and the real standing cost from month 2 is $199 (semaglutide) or $299 (tirzepatide)
- New York and New Jersey residents are explicitly called out as paying different pricing, but the site does not state the amount
Regulatory note: the FDA issued a warning letter to Joi and Blokes dba Joi + Blokes in June 2026. We still list and link to Joi + Blokes; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.