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WeighLab

Open Water Rx vs Ascend Vitality

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Open Water Rx

Provider comparison

Shoppers who want published monthly all-dose injection prices and separate oral options.

Semaglutide / month
$169/moAll doses, monthly compounded injection program
Tirzepatide / month
$219/moAll doses, monthly compounded injection program
Index 78/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Open Water Rx pricing Read review

Ascend Vitality

Provider comparison

Cash-pay shoppers who want compounded semaglutide as an injection or a daily tablet, month to month, with no membership fee.

Semaglutide / month
$199/mo1-month plan, compounded
Tirzepatide / month
$249/mo1-month plan, compounded
Index 77/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Ascend Vitality pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Open Water Rx has the higher Cost-Efficiency Index: 78/100 versus 77/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Open Water Rx

Ascend Vitality

Semaglutide / month
Open Water Rx: $169/moAll doses, monthly compounded injection program
Ascend Vitality: $199/mo1-month plan, compounded
Tirzepatide / month
Open Water Rx: $219/moAll doses, monthly compounded injection program
Ascend Vitality: $249/mo1-month plan, compounded
Semaglutide / year (modeled)
Open Water Rx: $2,028
Ascend Vitality: $2,388
Tirzepatide / year (modeled)
Open Water Rx: $2,628
Ascend Vitality: $2,988
State availability
Open Water Rx: All 50 states
Ascend Vitality: All 50 states
Oral / sublingual option listed
Open Water Rx: Yes
Ascend Vitality: Yes
Brand-name access listed
Open Water Rx: Not confirmed
Ascend Vitality: Not confirmed
Provider facts checked
Open Water Rx: October 2026
Ascend Vitality: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Open Water Rx

Shoppers who want published monthly all-dose injection prices and separate oral options.

Reasons to consider it

  • One-month injection plans have no dose-based price increase
  • Clinical review, medication if prescribed, shipping and follow-up are included
  • Oral semaglutide and tirzepatide have separate published prices

What to weigh up

  • Multi-month plans require prepayment; confirm the total before buying
  • Cancel at least 72 hours before the next billing date
  • The homepage says no charge before approval, while its cancellation policy describes payment at checkout and a refund if declined

Compounded drugs are not FDA-approved. Understand the medication options.

Check Open Water Rx pricing Read the full Open Water Rx review

Ascend Vitality

Cash-pay shoppers who want compounded semaglutide as an injection or a daily tablet, month to month, with no membership fee.

Reasons to consider it

  • Publishes month-to-month prices: semaglutide injections or tablets $199 and tirzepatide $249 a month, with no membership fee
  • Semaglutide comes as a weekly injection or a daily tablet
  • Three-month plans cut the first three months to $297 for semaglutide injections and $447 for tirzepatide

What to weigh up

  • The three-month prices are for your first three months only, and the site doesn't say what the renewal costs
  • No named medical director or prescriber, and the compounding pharmacies aren't named
  • All sales are final, with no refunds once the evaluation is done

Compounded drugs are not FDA-approved. Understand the medication options.

Check Ascend Vitality pricing Read the full Ascend Vitality review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

Open Water RxAscend Vitality
Normalized Cost/Month
Open Water Rx:
81/100
Ascend Vitality:
67/100
Price Transparency
Open Water Rx:
94/100
Ascend Vitality:
86/100
Nationwide Access
Open Water Rx:
86/100
Ascend Vitality:
86/100
Formulation Options
Open Water Rx:
77/100
Ascend Vitality:
77/100
Clinical Oversight
Open Water Rx:
59/100
Ascend Vitality:
74/100
Contract Flexibility
Open Water Rx:
55/100
Ascend Vitality:
73/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.