Head-to-head · Cost-Efficiency Index
Mondae vs Enhance MD
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Mondae
Cost-first shoppers who want a low all-in price with no membership attached and will count 13 billing cycles a year.
Visit MondaeEnhance MD
Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Visit Enhance MDThe verdict
Mondae takes it, leading the Cost-Efficiency Index 79 to 75. Mondae charges $87 for compounded semaglutide and $126 for tirzepatide every 28 days, with the medication, the supplies, unlimited clinician messaging and shipping inside the figure and no consultation or membership fee. Enhance MD still earns a C — Shoppers who want to see every price on the ladder before they commit, value dose-flat billing and routine lab monitoring, and don't need a brand-name or oral route.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Mondae.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Mondae | Enhance MD |
|---|---|---|
| Cost-Efficiency Index | 79/100 | 75/100 |
| Semaglutide / mo | $87 every 28 days month-to-month (13 charges a year; the advertised $75 is the three-month prepay) | $212/mo (first month $112) |
| Tirzepatide / mo | $126 every 28 days month-to-month (the advertised $124 is the three-month prepay) | $280/mo (first month $180) |
| Semaglutide / yr (modeled) | $1,044 | $2,544 |
| Tirzepatide / yr (modeled) | $1,512 | $3,360 |
| Coverage | All 50 states | Not disclosed |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #37 | #43 |
Mondae
79/100Where the value is
- A low all-in figure on both molecules, with the medication, the injection supplies, unlimited clinician messaging and discreet shipping all inside it
- No membership fee and no consultation fee are charged on top of the medication price
- The three-month rate for each molecule is shown by a control on the same page, so the commitment and the monthly rate can be compared directly
The tradeoffs
- "From $75/mo" and "From $124/mo" on the homepage are the three-month prepay rates; the month-to-month rates are $87 and $126
- Billing is every 28 days rather than monthly, so a year costs 13 charges rather than 12
Enhance MD
75/100Where the value is
- Fully published, dose-flat tiered pricing — sema $212/mo, tirz $280/mo, microdose $169/mo, sema+tirz combo $322/mo — no quiz or quote wall
- The rate does not climb as your dose is titrated up, unlike per-mg pricing elsewhere in this ranking
- Routine lab work at the 6-month mark plus ongoing provider messaging is bundled into the price, not sold separately
The tradeoffs
- Compounded only — no FDA-approved brand-name route (no Wegovy, Ozempic, Mounjaro or Zepbound)
- No oral or sublingual GLP-1 option (injection only)
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.