Head-to-head · Cost-Efficiency Index
Medsol RX vs Yes Clinic
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Medsol RX
Shoppers who will actually commit to a 12-month prepay and want the lowest possible locked-in monthly rate.
Visit Medsol RXYes Clinic
Shoppers who can pay for three months at once and want a price that won't rise as their dose goes up.
Visit Yes ClinicThe verdict
Medsol RX and Yes Clinic tie on the Cost-Efficiency Index at 65/100, so neither wins outright on the numbers, so choose on fit. Medsol RX: Shoppers who will actually commit to a 12-month prepay and want the lowest possible locked-in monthly rate. Yes Clinic: Shoppers who can pay for three months at once and want a price that won't rise as their dose goes up.
Worth knowing either way: CoreAge Rx is one of our partners and leads our leaderboard, where partners are listed first (Cost-Efficiency Index 94/100). See how it stacks up: CoreAge Rx vs Medsol RX.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Medsol RX | Yes Clinic |
|---|---|---|
| Cost-Efficiency Index | 65/100 | 65/100 |
| Semaglutide / mo | $199/moCompounded | $129/mo3-month plan, billed $387 upfront, same price at every dose, compounded |
| Tirzepatide / mo | $259/moCompounded | $149/mo3-month plan, billed $447 upfront, same price at every dose, compounded |
| Semaglutide / yr (modeled) | $2,388 | $1,548 |
| Tirzepatide / yr (modeled) | $3,108 | $1,788 |
| Coverage | All 50 states | Not published |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #204 | #211 |
Medsol RX
65/100Where the value is
- Every commitment tier bundles a dedicated care coach, custom treatment plan, and medical oversight at no extra charge
- Genuine month-to-month option exists with no long-term lock-in, unlike some peers that require prepay
- HSA/FSA eligible with Klarna financing offered
The tradeoffs
- The eye-catching $129/$199 headline prices require a full 12-month prepay ($1,548-$2,388 charged upfront) — the flexible month-to-month rate is $199/$259, notably higher
- No compounding pharmacy is named — only a generic 'certified U.S. pharmacies' claim
Yes Clinic
65/100Where the value is
- Every plan price is on the product pages with no quiz or account: semaglutide $387 for 3 months or $699 for 6, tirzepatide $447 or $894
- The price stays the same at every dose, and the online consultation, shipping and membership are all included at $0
- If a provider declines to prescribe, you aren't charged for medication, and a 6-month plan refunds months 4 to 6 if they aren't approved
The tradeoffs
- There is no single-month plan: the cheapest way in is three months paid upfront
- The homepage says GLP-1 programs start "From $199/month" and mentions monthly plan rates, while the product pages show only $129 and $149 a month on 3- and 6-month plans
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.