Head-to-head · Cost-Efficiency Index
MediRX vs SkyRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
MediRX
Shoppers who want transparent published pricing and don't mind that prescribing is handled by a third-party clinician network (OpenLoop) rather than an in-house medical team.
Visit MediRXSkyRx
Shoppers willing to commit and prepay a full year upfront in exchange for a lower blended monthly rate.
Visit SkyRxThe verdict
MediRX and SkyRx tie on the Cost-Efficiency Index at 55/100, so neither wins outright on the numbers. For most shoppers we'd start with MediRX (ranked #339, a hair above #346) — Shoppers who want transparent published pricing and don't mind that prescribing is handled by a third-party clinician network (OpenLoop) rather than an in-house medical team. But SkyRx is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs MediRX.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | MediRX | SkyRx |
|---|---|---|
| Cost-Efficiency Index | 55/100 | 55/100 |
| Semaglutide / mo | $149/mo (starting dose, compounded) | $199/mo (compounded) |
| Tirzepatide / mo | $199/mo (starting dose, compounded) | Not disclosed |
| Semaglutide / yr (modeled) | $1,788 | $2,388 |
| Tirzepatide / yr (modeled) | $2,388 | — |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #339 | #346 |
MediRX
55/100Where the value is
- Publishes specific dollar pricing for both injection and oral-tablet forms of both drugs
- Rare self-disclosed distinction between promotional ($149) and standard ($179) semaglutide pricing
- LegitScript badge displayed on the page
The tradeoffs
- MediRx itself has no named medical director -- all clinical care is outsourced to OpenLoop Health's network
- Tirzepatide's wide $199-$399 range makes the true likely monthly cost at a therapeutic dose unclear
SkyRx
55/100Where the value is
- Simple, single headline price displayed on the weight-loss page
- Claims LegitScript certification
- Straightforward telehealth intake flow
The tradeoffs
- The '$199/mo' price is a 12-month prepay rate, not a cancel-anytime monthly price -- a major disclosure trap
- Tirzepatide not yet available ('coming soon'), so half the category is unpriced
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.