Head-to-head · Cost-Efficiency Index
Medi-Weightloss vs Ryze Rx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Medi-Weightloss
Shoppers near one of Medi-Weightloss's 130+ US clinics who want in-person labs and are comfortable with location-dependent pricing.
Visit Medi-WeightlossRyze Rx
Cost-first shoppers who want compounded GLP-1s plus a broad TRT and peptide menu on one platform.
Visit Ryze RxThe verdict
Medi-Weightloss and Ryze Rx tie on the Cost-Efficiency Index at 54/100, so neither wins outright on the numbers. For most shoppers we'd start with Medi-Weightloss (ranked #358, a hair above #364) — Shoppers near one of Medi-Weightloss's 130+ US clinics who want in-person labs and are comfortable with location-dependent pricing. But Ryze Rx is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Medi-Weightloss.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Medi-Weightloss | Ryze Rx |
|---|---|---|
| Cost-Efficiency Index | 54/100 | 54/100 |
| Semaglutide / mo | $99/mo (starting dose, first-month rate, plus a separate fee, compounded) | $199/mo (starting dose, 3 month plan, compounded) |
| Tirzepatide / mo | $199/mo (starting dose, first-month rate, plus a separate fee, compounded) | $199/mo (starting dose, 3 month plan, compounded) |
| Semaglutide / yr (modeled) | $1,188 | $2,388 |
| Tirzepatide / yr (modeled) | $2,388 | $2,388 |
| Coverage | Coverage not published | Coverage not published |
| Oral / sublingual | No | No |
| Brand-name access | Yes | Compounded only |
| Rank here | #358 | #364 |
Medi-Weightloss
54/100Where the value is
- Over 130 in-person clinic locations across the US with on-site labs and body composition analysis at the new-patient visit
- Publishes real introductory numbers ($99 semaglutide / $199 tirzepatide first month) rather than staying fully opaque
- Insurance path available for branded Zepbound/Wegovy/Saxenda, with the site claiming most insured patients 'pay between $0 and $50 per visit'
The tradeoffs
- The $99/$199 headline figures are explicitly FIRST-MONTH-ONLY; the ongoing self-pay rate 'varies by program and location' and is never published anywhere on the site
- A separate $199 new-patient visit fee is charged before the first month's medication price even applies
Ryze Rx
54/100Where the value is
- Compounded semaglutide and tirzepatide both $199/mo, with $499/$799 three-month bundles
- Physician consultation, ongoing clinical support and discreet shipping included with each prescription
- Broad catalog beyond GLP-1: TRT plus peptides (BPC-157, sermorelin, NAD+, retatrutide and more)
The tradeoffs
- Terms, Privacy Policy and HIPAA notice are dead links - no legal entity, refund policy or governing law disclosed
- Pharmacy partners not named - only 'US-licensed compounding pharmacies'
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.