Head-to-head · Cost-Efficiency Index
Jyra Health vs SkinnyRx
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Jyra Health
Cost-first shoppers who want low compounded GLP-1 pricing if you're comfortable prepaying a 3-month plan.
Visit Jyra HealthSkinnyRx
Shoppers who have already decided on a long commitment and want the term priced openly rather than hidden behind an intake — not price-first shoppers comparing on the advertised figure.
Visit SkinnyRxThe verdict
Jyra Health takes it, leading the Cost-Efficiency Index 74 to 71. Jyra Health is a compounded GLP-1 telehealth clinic charging $175/mo (semaglutide) or $199/mo (tirzepatide) month-to-month, discounted to $139/mo and $179/mo respectively on a 3-month prepaid plan. SkinnyRx still earns a C — Shoppers who have already decided on a long commitment and want the term priced openly rather than hidden behind an intake — not price-first shoppers comparing on the advertised figure.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Jyra Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Jyra Health | SkinnyRx |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 71/100 |
| Semaglutide / mo | $175/mo (all doses, compounded) | $349/mo month-to-month ($299 on 4 months, $249 on 6, $199 only on 12) |
| Tirzepatide / mo | $199/mo (all doses, compounded) | $399/mo month-to-month ($349 on 4 months, $329 on 6, $299 only on 12) |
| Semaglutide / yr (modeled) | $2,100 | $4,188 |
| Tirzepatide / yr (modeled) | $2,388 | $4,788 |
| Coverage | All 50 states | Most states |
| Oral / sublingual | No | No |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #54 | #60 |
Jyra Health
74/100Where the value is
- Genuine, math-consistent 3-month prepay discount ($111 off semaglutide, $60 off tirzepatide across 3 months) rather than a vague 'up to X% off' claim
- Flat price at every dose with no renewal increase, on both the 1-month and 3-month tiers
- Claims all-50-state coverage with no membership fees and free express delivery
The tradeoffs
- The lower headline-friendly prices ($139/mo semaglutide, $179/mo tirzepatide) are only available by prepaying a full 3-month plan up front, not as a standing month-to-month rate
- No compounding pharmacy is named anywhere on the site
SkinnyRx
71/100Where the value is
- A complete four-term ladder for both molecules is published rather than gated, so the cost of not committing is knowable before signup
- Both compounded molecules are offered, with the same term structure on each
- The twelve-month rate is genuinely low for the category if a year is a commitment you were going to make anyway
The tradeoffs
- The '$199/month' it advertises everywhere is the TWELVE-MONTH rung. The rate you can stop after a month is $349 — 75% higher — and the figure appears without that term attached
- An FDA warning letter is on public record against Lean Rx, Inc. dba SkinnyRx, issued 20 February 2026. We disclose it and we do not treat it as disqualifying
Regulatory note: the FDA issued a warning letter to Lean Rx, Inc. dba SkinnyRx in February 2026. We still list and link to SkinnyRx; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.