Head-to-head · Cost-Efficiency Index
Jyra Health vs Direct Meds
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Jyra Health
Cost-first shoppers who want low compounded GLP-1 pricing if you're comfortable prepaying a 3-month plan.
Visit Jyra HealthDirect Meds
Needle-averse shoppers who want a sublingual route on either molecule and will pay above the going rate for it, having accepted a three-month supply as the smallest unit sold.
Visit Direct MedsThe verdict
Jyra Health takes it, leading the Cost-Efficiency Index 74 to 71. Jyra Health is a compounded GLP-1 telehealth clinic charging $175/mo (semaglutide) or $199/mo (tirzepatide) month-to-month, discounted to $139/mo and $179/mo respectively on a 3-month prepaid plan. Direct Meds still earns a C — Needle-averse shoppers who want a sublingual route on either molecule and will pay above the going rate for it, having accepted a three-month supply as the smallest unit sold.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Jyra Health.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Jyra Health | Direct Meds |
|---|---|---|
| Cost-Efficiency Index | 74/100 | 71/100 |
| Semaglutide / mo | $175/mo (all doses, compounded) | $249/mo (sublingual, 90-day supply billed monthly) |
| Tirzepatide / mo | $199/mo (all doses, compounded) | $299/mo (sublingual, 90-day supply billed monthly) |
| Semaglutide / yr (modeled) | $2,100 | $2,988 |
| Tirzepatide / yr (modeled) | $2,388 | $3,588 |
| Coverage | All 50 states | Not disclosed |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #59 | #64 |
Jyra Health
74/100Where the value is
- Genuine, math-consistent 3-month prepay discount ($111 off semaglutide, $60 off tirzepatide across 3 months) rather than a vague 'up to X% off' claim
- Flat price at every dose with no renewal increase, on both the 1-month and 3-month tiers
- Claims all-50-state coverage with no membership fees and free express delivery
The tradeoffs
- The lower headline-friendly prices ($139/mo semaglutide, $179/mo tirzepatide) are only available by prepaying a full 3-month plan up front, not as a standing month-to-month rate
- No compounding pharmacy is named anywhere on the site
Direct Meds
71/100Where the value is
- Sublingual AND injection on BOTH molecules — four GLP-1 SKUs, the widest formulation range of any provider in this ranking
- Every price is published per SKU in a public shop, with no quiz, intake or email capture in front of it
- Each product page prints a per-day equivalent beside the monthly rate ($8.03/day at $249), which is unusually concrete for this category
The tradeoffs
- $249/mo sublingual is well above this ranking's ~$144 median, and the injection route is $297 — the cheapest thing here is dearer than most rows' headline price
- The only purchasable option on every product page is a 90-DAY SUPPLY billed monthly, so three months is the smallest unit sold — there is no month-to-month rate to compare against the rows beside it
Regulatory note: the FDA issued a warning letter to directmeds.com, Inc. dba DirectMeds in September 2025. We still list and link to Direct Meds; you should know the letter is on the public record before you decide.
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.