Head-to-head · Cost-Efficiency Index
Joi + Blokes vs PCOS Sisters
Two GLP-1 programs on the bench, scored on the same six factors. Here's how their real cost of ownership compares — and which one we'd start with.
Joi + Blokes
Patients already on Joi or Blokes hormone programs who want GLP-1 added under the same clinician relationship, and are comfortable with a 3-month billing commitment.
Visit Joi + BlokesPCOS Sisters
Cost-first shoppers who want women with PCOS who want GLP-1 prescribing folded into a specialty metabolic-care membership.
Visit PCOS SistersThe verdict
Joi + Blokes and PCOS Sisters tie on the Cost-Efficiency Index at 52/100, so neither wins outright on the numbers. For most shoppers we'd start with Joi + Blokes (ranked #384, a hair above #390) — Patients already on Joi or Blokes hormone programs who want GLP-1 added under the same clinician relationship, and are comfortable with a 3-month billing commitment. But PCOS Sisters is a genuine coin-flip alternative here.
Worth knowing either way: our overall #1 pick is CoreAge Rx (Cost-Efficiency Index 94/100 — the top of the ranking). See how it stacks up: CoreAge Rx vs Joi + Blokes.
Factor by factor
Both providers scored on our six Cost-Efficiency Index factors. The stronger side on each row is marked in teal.
Normalized Cost/Month
Price Transparency
Nationwide Access
Formulation Options
Clinical Oversight
Contract Flexibility
Pricing, coverage & formulary
The disclosed facts behind the scores. Lower price wins its row (teal).
| Spec | Joi + Blokes | PCOS Sisters |
|---|---|---|
| Cost-Efficiency Index | 52/100 | 52/100 |
| Semaglutide / mo | $199/mo (quarterly plan, compounded) | Not disclosed |
| Tirzepatide / mo | $299/mo (quarterly plan, compounded) | Not disclosed |
| Semaglutide / yr (modeled) | $2,388 | — |
| Tirzepatide / yr (modeled) | $3,588 | — |
| Coverage | Coverage not published | 12 states |
| Oral / sublingual | No | Yes |
| Brand-name access | Compounded only | Compounded only |
| Rank here | #384 | #390 |
Joi + Blokes
52/100Where the value is
- Named Medical Director, Dr. Melissa Loseke, DO, plus a named Head Nurse Practitioner and two named Medical Advisors — real clinical attribution not disclosed by most competitors in this batch
- Separate gender-specific programs (Joi for women, Blokes for men) built around hormone health, with GLP-1 added as an integrated option alongside testosterone/perimenopause protocols
- For FDA-approved GLP-1/GIP medications specifically, insurance is accepted and the prescription routes to the patient's own local pharmacy rather than a mail-order compounder
The tradeoffs
- Billed in 3-month blocks, not month-to-month — the $99/$149 first-month price is promotional, and the real standing cost from month 2 is $199 (semaglutide) or $299 (tirzepatide)
- New York and New Jersey residents are explicitly called out as paying different pricing, but the site does not state the amount
Regulatory note: the FDA issued a warning letter to Joi and Blokes dba Joi + Blokes in June 2026. We still list and link to Joi + Blokes; you should know the letter is on the public record before you decide.
PCOS Sisters
52/100Where the value is
- Dedicated PCOS specialty model with a metabolic weight-loss program and fitness app bundled into the membership
- Two named pharmacy partners with full addresses published (Strive Pharmacy, Gilbert AZ; Striker Pharmacy, Katy TX)
- LegitScript and BBB verification badges both present on-site
The tradeoffs
- The advertised $150/month does NOT include the GLP-1 medication itself — the site's own FAQ confirms medication is billed separately by the pharmacy, so the real all-in cost is higher and undisclosed
- Only 11 states served (not 12), with no public timeline for expansion beyond 'working to expand our coverage'
Assume any provider we list may compensate us — we may earn a commission, at no cost to you. It never changes the Cost-Efficiency Index. Pricing, states and verification reflect each provider's public disclosures at last review; prices change — confirm on the provider's site. Not medical advice. See our disclosure.