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WeighLab

Fitstry vs Direct Meds

Compare the prices, treatment options and tradeoffs that matter before you choose a GLP-1 program.

By The WeighLab Bench. Provider verification dates appear below.

Fitstry

Provider comparison

Shoppers who want month-to-month compounded GLP-1 pricing with coaching, labs and a named physician setting the protocols.

Semaglutide / month
$249Every 4 weeks (month-to-month, compounded; daily tablet $279)
Tirzepatide / month
$339Every 4 weeks (month-to-month, compounded)
Index 74/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Fitstry pricing Read review

Direct Meds

Affiliate partner

Needle-averse shoppers who want a sublingual route on either molecule and will pay above the going rate for it, having accepted a three-month supply as the smallest unit sold.

Semaglutide / month
$249/moSublingual, 90-day supply billed monthly
Tirzepatide / month
$299/moSublingual, 90-day supply billed monthly
Index 71/100 · Grade CChecked October 2026

Compounded drugs are not FDA-approved. Understand the medication options.

Check Direct Meds pricing Read review

We may earn a commission if you sign up through a provider link, at no extra cost to you. Compensation does not change scores. How we earn money.

The comparison in brief

Fitstry has the higher Cost-Efficiency Index: 74/100 versus 71/100. That is a value comparison under our published methodology, not a measure of medical suitability or a guarantee of results.

Check the difference in state access

Fitstry
49 states
Direct Meds
Not disclosed

The better fit depends on what is included in your quote. A lower advertised price can require prepayment, apply to a starting dose or leave out a separate fee.

How the comparison is scored

Costs & coverage

Published prices with their terms intact. Annual estimates account for billing frequency and known fixed required fees; they are not a treatment quote.

Fitstry

Direct Meds

Semaglutide / month
Fitstry: $249Every 4 weeks (month-to-month, compounded; daily tablet $279)
Direct Meds: $249/moSublingual, 90-day supply billed monthly
Tirzepatide / month
Fitstry: $339Every 4 weeks (month-to-month, compounded)
Direct Meds: $299/moSublingual, 90-day supply billed monthly
Semaglutide / year (modeled)
Fitstry: $3,23713 charges
Direct Meds: $2,988
Tirzepatide / year (modeled)
Fitstry: $4,40713 charges
Direct Meds: $3,588
State availability
Fitstry: 49 states
Direct Meds: Not disclosed
Oral / sublingual option listed
Fitstry: Yes
Direct Meds: Yes
Brand-name access listed
Fitstry: Not confirmed
Direct Meds: Not confirmed
Provider facts checked
Fitstry: October 2026
Direct Meds: October 2026

Comparing different billing plans? See what a GLP-1 monthly price can leave out, or calculate the monthly cost.

Which program fits your priorities?

The strengths and limitations behind each provider's score. Read the full review before deciding.

Fitstry

Shoppers who want month-to-month compounded GLP-1 pricing with coaching, labs and a named physician setting the protocols.

Reasons to consider it

  • Publishes month-to-month prices: compounded semaglutide $249, tirzepatide $339 and a daily tablet $279, cancel any time
  • No program fee for now, and the first month is refunded in full if a clinician doesn't approve you
  • Clinical protocols set by a named board-certified physician, Dr. Sergio Naccarato, MD

What to weigh up

  • Bills every four weeks, so a year is 13 charges, not 12
  • The lower 'starting at' prices on its cards aren't tied to a stated plan length
  • The program fee is waived only for a limited time, and its amount isn't published

Compounded drugs are not FDA-approved. Understand the medication options.

Check Fitstry pricing Read the full Fitstry review

Direct Meds

Needle-averse shoppers who want a sublingual route on either molecule and will pay above the going rate for it, having accepted a three-month supply as the smallest unit sold.

Reasons to consider it

  • Sublingual and injection on both molecules, so four GLP-1 products to choose from
  • Every price is published per SKU in a public shop, with no quiz, intake or email capture in front of it
  • Each product page prints a per-day equivalent beside the monthly rate ($8.03/day at $249), which is unusually concrete for this category

What to weigh up

  • $249 a month for the sublingual and $297 for the injection cost more than many programs we track charge for an injection
  • The only purchasable option on every product page is a 90-DAY SUPPLY billed monthly, so three months is the smallest unit sold — there is no month-to-month rate to compare with programs you can cancel after one month
  • Every headline figure is framed "AS LOW AS", yet the only available option shows "0% OFF" — the framing implies a cheaper tier that is not actually on sale

Regulatory note: the FDA issued a warning letter to directmeds.com, Inc. dba DirectMeds in September 2025. We still list and link to Direct Meds; you should know the letter is on the public record before you decide.

Compounded drugs are not FDA-approved. Understand the medication options.

Check Direct Meds pricing Read the full Direct Meds review

Explore the six scoring factors

Scores run from 0 to 100. A higher factor score reflects our published value criteria; it is not a clinical endorsement.

FitstryDirect Meds
Normalized Cost/Month
Fitstry:
56/100
Direct Meds:
62/100
Price Transparency
Fitstry:
86/100
Direct Meds:
78/100
Nationwide Access
Fitstry:
78/100
Direct Meds:
60/100
Formulation Options
Fitstry:
77/100
Direct Meds:
96/100
Clinical Oversight
Fitstry:
81/100
Direct Meds:
68/100
Contract Flexibility
Fitstry:
77/100
Direct Meds:
66/100

Before you sign up

  • Confirm your totalAsk about dose changes, membership, labs, shipping and cancellation terms.
  • Check treatment accessState coverage and medical eligibility can differ by medication and formulation.
  • Understand the medicationCompare compounded and brand-name options. Compounded drugs are not FDA-approved.

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Provider information reflects public disclosures at the verification dates shown. Prices and availability change; confirm current terms before paying. This comparison is for information, not medical advice. A licensed clinician determines whether treatment is appropriate.